| 摘要: |
| 目的 探讨PLGA经主动脉心肌造影联合多巴酚丁胺负荷条件下,二维应变评价节段心肌存活性的准确性。方法 30只杂种犬建立急性心肌缺血再灌注模型,经主动脉根部行PLGA心肌造影,通过多巴酚丁胺负荷试验,获取心肌节段二维应变参数。结果 多巴酚丁胺负荷后,非存活节段的收缩期二维峰值应变较静息时无明显升高。存活节段的应变值随剂量增加而升高,与非存活节段比较,二者间有统计学显著性差异。结论 PLGA心肌造影联合多巴酚丁胺负荷试验可以提高超声图像质量,获取二维应变参数,提高评价心肌存活的准确性。 |
| 关键词: 多巴酚丁胺,负荷超声心动图,二维应变,存活心肌 |
| DOI： |
| 投稿时间：2016-02-25修订日期：2016-04-12 |
| 基金项目:重庆市科委基础与前沿计划一般项目(cstc2013jcyjA10052)；重庆市卫生计生委2015年医学科研计划项目(2015MSXM024) |
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| Experimental assessment of myocardial viability by two-dimensional strain analyses during PLGA contrast enhanced dobutamine stress echocardiography |
| Qunxia Zhang,Min Lu |
| (Department of Ultrasonography,the Second Affiliated Hospital,Chongqing Medical University) |
| Abstract: |
| Objective The aim of this study was to access method by which identify viable myocardium by two-dimensional strain analysis combined with PLGA contrast enhanced low dose dobutamine stress echocardiography. Methods Thirty cute ischemia reperfusion canine models were reproduced successfully. While real-time myocardial contrast (enhanced with PLGA contrast agents) performed, images were acquired and saved at baseline, rest , and the period low dose dobutamine administration. Measurements of regional peak-systolic strain in longitudinal, radial and circumferential motion on all segments were performed respectively under different condition. Results Compared with nonviable myocardial segment, LS, RS and CS of viable segment increased significantly during dobutamine stress (p <0.05; p <0.01), and LS, RS and CS of the former did not present significant variance at same time (p >0.05). Respective sensitivities for LS, RS, and CS were 81.03%, 77.59%, and 72.41%; respective specificities were 81.3%, 84%, and 78%. Conclusion Two-dimensional strain analysis combined with low dose dobutamine stress echocardiography enhanced with PLGA contrast agent can afford a novel way to distinguish viable myocardium from the non-viable myocardium with a incremental accuracy. |
| Key words: Stress echocardiography Two dimensional strain Viable myocardium Dobutamine |
