Abstract: Objective To examine the intracranical hemorrhage of newborns using ultrasound and MRI and compare the diagnosis value between the two test methods. Methods 335 newborns suspected to be intracranical hemorrhage were examined by both ultrasound and MRI. The diagnosis results were compared and analyzed. Results Of all the cases, the ultrasound make 315 right diagnoses and 20 wrong diagnosis; while the MRI make 323 right diagnoses and 12 wrong diagnoses. Between the two test methods, The results of the first level of intraventricular hemorrhage, subdural hematoma and subarachnoid hemorrhage have significant differences (P≤0.05); while the results of other types of cerebral hemorrhage are not statistically different (P＞0.05). Considering the respects of sensitivity, specificity and accuracy, the results of ultrasound were 100% in the case of the first level of intraventricular hemorrhage; while the results of MRI were 94%、100%、94% respectively. The results of ultrasound were respectively 78%、100%、80% in the case of subdural hematoma; while the results of MRI were all 100%. The results of ultrasound were respectively 77%、100%、79% in the case of subarachnoid hemorrhage; while the results of MRI were all 100%. Conclusion There are advantages and disadvantages in the the diagnosis of intracranial hemorrhage of newborns using ultrasound and MRI. With respect to high risk infants, ultrasound can be firstly used particularly for premature infant and MRI for further examination.