Objective To investigate the value of ultrasonic elastography combining with cervical lymph nodes probe in differential diagnosis of benign and malignant thyroid nodules. Methods Ninety-five patients with thyroid nodules (total119 nodules) were examined by ultrasonic elastography, meanwhile whose cervical lymph nodes were probed. All of the nodules were diagnosed by pathology of surgery or puncture. We combine the two methods to identify benign and malignant thyroid nodules, then contrast with pathology to investigate the value of this method. Results The sensitivity, specificity of ultrasonic elastography combining with cervical lymph nodes probe to diagnose thyroid nodules with elastic three points were 80%、91.7%,to diagnose thyroid nodules with elastic four points were 94.1%、75%, to diagnose thyroid nodules with elastic five points were 94.7%、100%. Contrast with simple ultrasonic elastography, the sensitivity specificity was significantly improved in thyroid nodules than elastic three points and five points, the sensitivity was significantly improved in thyroid nodules than elastic three points(P<0.01). Conclusion Ultrasonic elastography combining with cervical lymph nodes probe significantly improved the accuracy in differential diagnosis of benign and malignant thyroid nodules. This method has a high value in clinical application.