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肾实质剪切波速度与转化生长因子-β1在糖尿病肾病中的相关性研究 |
郑毅 |
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(华中科技大学同济医学院附属协和医院超声影像科) |
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摘要: |
目的 观察2型糖尿病肾病患者(DN)的肾实质剪切波速度(SWV)和血清中转化生长因子-β1(TGF-β1)变化,探讨二者相关性。方法 用声触诊组织量化技术(VTQ)检测T2DM组(90例)及同期门诊健康体检者 D 组(30例)人群肾实质SWV;并利用ELISA法检测各组人群血清中TGF-β1水平。根据尿微量白蛋白/肌酐值(ACR)范围,将T2DM组分为正常白蛋白尿A组30例(ACR<30 mg/g),微量白蛋白尿B组30例(30≤ACR≤300 mg/g),临床白蛋白尿C组30例(ACR>300 mg/g)。比较各组间的TGF-β1水平及肾实质SWV,并对二者进行相关性分析。结果 T2DM组患者血清中的TGF-β1水平及肾实质SWV测值较健康对照组均明显升高。SWV测值:C组>B组>A组(P<0.05);TGF-β1水平:A组与B组比较未见统计学差异( P>0.05),A组与C组比较有统计学差异(P<0.05)。肾实质SWV与血清TGF-β1之间存在显著正相关(r=0.624,P<0.05)。结论 肾实质SWV测值和血清TGF-β1的表达会随DN的进展而升高 ,二者在糖尿病肾病诊治中有重要的应用价值。 |
关键词: 剪切波速度 转化生长因子-β1 糖尿病肾病 |
DOI: |
投稿时间:2016-03-21修订日期:2016-06-27 |
基金项目:华中科技大学自主创新基金;国家自然科学基金青年基金 |
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Correlation Study Between the Renal Parenchyma Shear Wave Velocity and Transforming Growth Factor-β1 in the Diagnosis and Treatment of Diabetic NephropathyZheng Yi, Zhang Yanrong, Hong Liu, Zhang Dan, Song Yue |
ZhengYi |
(Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Provincial Key Laboratory of Molecular Imaging,) |
Abstract: |
Objective To analyze the changes of renal parenchyma shear wave velocity (SWA) and plasma level of transforming growth factor-β1(TGF-β1) in patients with diabetic nephropathy (DN) and discuss their correlations. Method Totally 90 patients with type II diabetes mellitus (T2DM) were enrolled and divided into 3 groups according to the albumin creatinine ratio (ACR): Group A (pre-nephropathy stage: ACR<30mg/g, n=30), Group B (microalbuminuria: 30mg/g≤ACR≤300mg/g, n=30) and Group C (clinical albuminuria: ACR>300mg/g, n=30). Meanwhile, 30 healthy people accepted heath examination in contemporaneity were included and marked as Group D. Virtual touch quantification (VTQ) technique and enzyme linked immunosorbent assay (ELISA) were performed in each group to access the SWA and plasma level of TGF-β1 respectively. Result Patients with DN had higher SWA and plasma level of TGF-β1 compared with Group D. Of those patients with DN, as the ACR increased, SWV elevated (Group C>Group B>Group A, P<0.05). The difference of plasma level of TGF β1 between Group A and Group C was statistically significant (P<0.05), while there was no statistical difference between Group A and Group B. Renal parenchyma SWA and plasma level of TGF-β1 were positively correlated (r = 0.624, P<0.05). Conclusion Both SWA and plasma level of TGF-β1 increased as the DN progressed. The SWA and plasma level of TGF-β1 may be the preferred examination methods for the diagnosis and treatment of DN. |
Key words: Shear wave velocity Transforming growth factor-β1 Diabetic nephropathy |
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