| 摘要: |
| 目的 探讨三维斑点追踪技术在检测糖尿病前期患者左心室亚临床心肌损伤中的价值。方法：选择不合并高血压的糖尿病前期患者41例，同期选择年龄、性别相匹配的健康人40例作为对照。采用三维斑点追踪技术测量两组左心室三维整体纵向应变(3D-GLS) 、三维整体面积应变(3D-GAS)、三维整体径向应变(2D-GRS)以及三维整体圆周应变(2D-GCS)。结果：两组LVEF无统计学差异(P＞0.05)。与对照组比较，糖尿病前期患者左心室3D-GLS显著减低(P ＜0.05)， 3D-GRS、3D-GAS无显著减低(P＞0.05)。相关性分析显示：糖尿病组3D-GLS与其腰臀比（r=-0.534，P=0.003）、BMI（r=-0.443，P=0.01）以及HbA1c（r=-0.587，P＜0.001）线性负相关, 多变量回归分析显示，HbA1c是左心室纵向收缩功能减低的独立危险因素。 结论：糖尿病前期患者左心室出现显著的亚临床心肌损伤，三维斑点追踪技术测量左心室纵向应变是检测糖尿病前期患者左心室亚临床心肌损伤的敏感指标。 |
| 关键词: 三维斑点追踪超声心动图, 亚临床左心室心肌损伤, 糖尿病前期 |
| DOI： |
| 投稿时间：2016-04-06修订日期：2016-04-18 |
| 基金项目:陕西省社发攻关项目(2011k14-01-11),延安市社发攻关项目(2014kw-14) |
|
| Evaluation of subclinical left ventricular systolic dysfunction in patients with Prediabetes by Three-dimensional speckle tracking echocardiography*Corresponding Author：Departments of Ultrasonography, T The Yanan Peoples Hospital, E-mail：270284425@qq.com |
| ta sheng jun |
| (yanan people hospital) |
| Abstract: |
| Objective The aim of this study was to evaluate the role of three dimensional (3D) speckle tracking echocardiography (STE) in the detection of subclinical left ventricular (LV) myocardial injury in patients with prediabetes. Methods The study included 41 patients with prediabetes and 40 age- and gender- matched healthy individuals. Conventional echocardiographic parameters were measures and 3D Speckle tracking imaging of the peak systolic strain(3D-GLS, 3D-GAS, 3D-GCS and3D-GRS ) were recorded. Results LVEF, LVEDV, LVESV,and 3D-GRS, 3D-GAS, 3D-GCS were similar between prediabetes and controls (P＞0.05). 3D-GLS was significantly reduced in patients with prediabetes compared to controls (P<0.05).Correlation analysis showed that 3D-GLS negatively correlated with waist hip ratio（r=-0.534，P=0.003）, BMI（r=-0.443，P=0.01）and HbA1c（r=-0.587，P＜0.001）.Multivariate regression analysis showed that HbA1c is an independent risk factor for left ventricular longitudinal systolic dysfunction. Conclusion Patients with prediabetes have evidence of subclinical LV myocardial injury. Three-dimensional global longitudinal strain appears to be useful and sensitive index in detection of subclinical LV dysfunction in patients with prediabetes. |
| Key words: three dimensional speckle tracking echocardiography, left ventricular subclinical systolic dysfunction , prediabetes |
