| 摘要: |
| 【】目的 研究动脉导管未闭(PDA)对早产儿早期脑血流灌注的影响。方法 将胎龄≤35周、出生体质量≤2200g,生后3天确诊为症状性PDA的早产儿,分为动脉导管开放组(PDA组)及药物关闭动脉导管组(对照组)。在生后6-7天内对入选的62例患儿(PDA组30例,对照组32例)应用高频超声结合E-flow血流显像技术,行超心动图和颅脑超声检查,测量大脑中动脉(middle cerebral artery, MAC)、豆纹动脉(Lenticulostriate artery, LSA)、豆纹动脉终末段(the terminal artery of Lenticulostriate artery, tLSA)的血流参数,包括收缩期峰值流速(Vs)、舒张末期速度(Vd)、平均血流速度(Vm)、收缩期峰值流速与舒张末期速度比值(S/D)、阻力指数(RI)。采用t检验比较各组间的差别。 结果 入选的两组早产儿在胎龄及出生体质量方面差异无统计学意义。PDA组MCA、LSA、tLSA的Vd测值均明显低于对照组(P < 0.001),而上述三个阶段血管的血流S/D及RI均大于对照组,P < 0.001。两组早产儿MCA、LSA的Vs无明显差异(P > 0.05),而PDA组脑组织内细小血管tLSA的Vs则明显减低,P < 0.001。结论 高频超声结合E-flow显像技术可观察到合并PDA早产儿脑血流动力学改变,反应脑实质内细小动脉的低灌注、高阻力状态,为临床判断及积极干预PDA,稳定早产儿脑血流,避免脑损伤提供依据。 |
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| DOI： |
| 投稿时间：2016-04-13修订日期：2016-06-05 |
| 基金项目:东莞市科技计划医疗卫生重点项目(201210515000132) |
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| Study to the effect of patent ductus ateriosus on cerebral blood flow infusion |
| nie hong lian |
| () |
| Abstract: |
| Objective To explore the effect of patent ductus ateriosus on cerebral blood flow infusion in preterm infants. Methods: The research focus on the premature infants whose gestational period less than or equal to 35 weeks, birth weight less than or equal to 2200 gram and diagnosed with PDA born within 3 days. The experimental subjects are divided into two groups, the group of patent ductus arteriosus (PDA group), and the ductus ateriosus were closed (the control group). Using high-frequency color Doppler ultrasound with E-flow imaging to test the blood flow of MAC, LSA and tLSA of 62 cases (30 in PDA group, 32 in control group). The parameters including Vs, Vd, Vm, (S/D) and RI. Conducting a t-test to compare the result of the PDA group and the control group. Result: The statistics result of the gestational period and birth weight of the samples is not significant. The value of Vd of MCA, LSA and tLSA in the PDA group is significantly lower than the control group (p-value<0.001). The value of S/D and RI of MCA, LSA and tLSA in PDA group is significantly higher than the control group (p-value<0.001). There is no significantly difference of MCA, LSA’s Vs value between the two groups. The Vs of tLSA in the PDA group is significantly lower than the control group (p <0.001). Conclusion: The change of cerebral hemodynamic in premature infants with PDA was found by high-frequency ultrasound with E-flow color Doppler. It will be provide the basis to active intervention PDA, stabilize cerebral blood flow in the premature infants , avoid cerebral injury. |
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