Objective To evaluate virtual touch tissue imaging quantification（VTIQ）for differentiating lymphomas and reactive hyperplasia lymph node. Methods The sonograms of 45 lymphomas were reviewed and compared with 48 reactive hyperplasia lymph nodes underwent conventional ultrasound and VTIQ examinations. Shear wave velocities（SWVs）of lymphomas and reactive hyperplasia lymph nodes were measured. The receiver operating characteristic curve（ROC）was used to assess the value of VTIQ in differentiating lymphomas and reactive hyperplasia lymph nodes. Results SWV was 3.37±0.93m/s for lymphomas and 2.20±0.49m/s for nonspecific reactive lymph nodes（T=11.498，P值0.001）. The SWVs between lymphomas and reactive hyperplasia lymph nodes were significantly different.（P=0.001)．Comparison of the lymphomas and the lymphatic system diseases, The AUC was 0.904 and the SWV cut-off value was 2.54m/s,the accuracy was 88.2%，sensitivity was 88.9%, specificity was 87.5%,positive predictive value was 87%，negative predictive value was 89.4%,odds ratio was 56.Conclusion VTIQ is valuable in differentiating cervical lymphomas and reactive hyperplasia lymph node