| 摘要: |
| 评价新型剪切波弹性成像技术对前列腺癌的诊断价值。方法 回顾性分析49例前列腺癌患者（前列腺癌组）和15例前列腺良性病变患者（良性病变组）的剪切波弹性成像资料，测量并比较其杨氏模量值；绘制平均杨氏模量值诊断前列腺癌的受试者工作特征曲线，确定其诊断界值并计算其敏感性、特异性、阳性预测值、阴性预测值、诊断准确率及曲线下面积；分析可疑病灶区与邻近周缘带内正常组织的平均杨氏模量值之比（Eration）与前列腺Gleason评分之间的相关性。结果 前列腺癌组杨氏模量值为（Emin44.3±11.2、Emax73.2±15.9Kpa、Emean57.6±11.7Kpa、Eration5.8±2.9 ），良性病变组杨氏模量值为（Emin24.3±10.5Kpa、Emax42.2±9.7Kpa、Emean、30.3±10.4Kpa、Eration2.8±1.3），两组比较，（差异有统计学意义，p值分别为0.020、0.018、0.013、0.010）。平均杨氏模量值诊断前列腺癌的ROC曲线：当Emean截断点选为41KPa时，诊断效率较高。（敏感度91%，特异度78%，阳性预测值64.6%，阴性预测值为95.3%，曲线下面积是0.934） Gleason评分为8分、9分的前列腺癌组织的Eration要明显高于Gleason评分为6、7分的组织，二者之间p值＜0.001。结论 经直肠剪切波弹性对于前列腺癌的诊断价值较好，具有较高的诊断准确率。 |
| 关键词: 剪切波弹性成像 前列腺癌 经直肠超声 |
| DOI： |
| 投稿时间：2016-04-28修订日期：2017-04-12 |
| 基金项目:甘肃省卫生行业科研计划项目 |
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| The Clinical Value Of Shear Wave Elastography For The Diagnosis Of Prostate Cancer |
| Sunting |
| (NO.2 Hospital Of Lanzhou University) |
| Abstract: |
| Objective This thesis mainly concerning the value of shear wave elastography in the diagnosis of prostate cancer. Methods We retrospectively analyzed the shear wave elastic imaging of 49 patients with prostate cancer and 15 patients with benign prostatic lesions. The Young's value of the suspected modulus were measured and compared. We plotted ROC curve of the Emean to determine the diagnostic threshold and to calculate the sensitivity, specificity, positive predictive value, negative predictive value, diagnostic accuracy.We analyzed the correlation between the Eration and the Gleason score .Results The malignant group:Emin44.3±11.2Kpa、Emax73.2±15.9Kpa、Emean、57.6±11.7Kpa、Eration5.8±2.9 Kpa.The benign group:Emin24.3±10.5Kpa、Emax42.2±9.7Kpa、Emean、30.3±10.4Kpa、Eration2.8±1.3.There are statistically difference between the two group,the value of p are0.020、0.018、0.013、0.010.The Eration of Gleason score 8 and 9 points were significantly higher than the Gleason score of 6,7 points . The p value between them was below 0.001 .According to the ROC curve,taking Emean41kPa as a cut-off，diagnostic efficiency is better. the sensitivity was 90%, the specificity was 78%, the positive predictive value was 64.6%, the negative predictive value was 95.3%, the area under the curve was 0.923.Conclusion The diagnostic value of transrectal shear wave elastography for prostate cancer is better，have a higher detection accuracy. |
| Key words: shear wave elastography transrectal ultrasound prostate cancer |
