Objective To investigate the value of quantitative ultrasound elastic parameters in NPBL. Methods Patients with NPBL who met the inclusion criteria in our hospital between January 2013 and June 2015 were recruited. They were divided into benign lesions group (Group A, n=110) , malignant lesions group (Group B, n=40) according to surgical-pathological results. Patients were examined with mammography,two dimensional ultrasonography and elastography．The SR, the rate change in diameter, the area ratio between Group A and B were compared and analyzed. ROC curves were drawn to evaluate the AUC, diagnostic threshold, sensitivity and specificity of benign lesions and malignant lesions. Results Compared to Group A(2.86±1.51), Group B(6.04±2.53) showed significantly higher levels of SR (t=5.031；p=0.000)．The threshold of ROC Curve in diagnosing breast cancer was 5.22 with the sensitivity of 57.5％,the specificity of 96.4％ and AUC of 0.844. Compared with the rate change in diameter (0.17±0.09)and the area ratio(1.12±0.33)in Group A, patients in Group B have a significantly higher level the rate change in diameter(0.28±0.12) and the area ratio(1.96±0.28)(All P＜0.05). The combined indicator of SR, rate change in diameter and area ratio showed a better ability in diagnosis of breast lesion than the individual indicators (sensitivity 77.5%, specificity 94.5%, AUC 0.937). Conclusion Combined Quantitative ultrasound elastic parameters can effectively identify benign and malignant breast lesions.