【】Objective To explore the value of contrast-enchanced ultrasound(CEUS) with enhanced magnetic resonance imaging(enhanced MRI) in different area of PSA for prostate cancer detection. Methods 132 patients suspected prostate cancer patients were retrospectively analyzed and all the patients underwent CEUS and enhanced MRI. And all patients further performed prostate biopsy through transrectal for prostate cancer final diagnosis. The result pathological of biopsy were performed to evaluate the diagnostic value of CEUS and enhanced MRI in different area of PSA. Result When PSA in the range of 4.0ng/ml to 10.0ng/ml, in 4 cases of prostate cancer, CEUS, MRI enhancement and combined diagnosis were diagnosed correctly by 2 cases, 3 cases and 4 cases respectively. The specificity of CEUS, MRI and the combined application were 82%, 96%, 80% respectively. There were significant differences compare MRI enhancement and combined diagnosis in diagnosis of prostate cancer(p<0.05). When PSA in the range of 10.0ng/ml to 20.0ng/ml The sensitivity of CEUS, MRI and the combined application to the diagnosis of prostate cancer were 42.86%, 52.38% and 80.95% respectively, and the specificity was 73.68%, 68.42% and 63.16% respectively. When PSA more than 20.0ng/ml, in 32 cases of prostate cancer were all diagnosed correctly with three kinds of methods. Conclusion When PSA in the range of 4.0ng/ml to 10.0ng/ml, MRI enhanced diagnosis with high specificity. So the MRI enhanced has diagnostic advantage. When PSA in the range of 10.0ng/ml to 20.0ng/ml, the combined application of CEUS and MRI has high sensitivity. The combined application has the advantage of diagnosis. When PSA more than 20.0ng/ml, Simple CEUS check can improve the positioning accuracy of prostate biopsy. So CEUS diagnosis has advantages.