| 摘要: |
| 目的 利用三维超声评价克氯米芬治疗不孕症对子宫内膜容受性的影响,并探讨其妊娠结局的影响及价值。方法 采集在我院生殖中心接受克氯米芬促排卵治疗的不孕患者46例进入本研究。收集患者一般情况(年龄、体重指数、不孕年限、FSH、LH、用药前卵泡数),分别于用药前后经阴道三维超声测量子宫内膜容积、厚度、子宫内膜及内膜下的血流分布类型、Vl(血管指数)、FI(血流指数)、VFI(血管血流指数),PI(搏动指数)、S∕D(收缩峰速度与舒张末期速度比值)、RI(阻力指数)、PS(收缩期峰值)、ED(舒张末期血流速度),并追踪妊娠结局,按妊娠结局分为妊娠组与非妊娠组。结果 妊娠组与非妊娠组患者一般情况无统计学差异(P>0.05),用药前、后妊娠组与非妊娠组子宫内膜厚度、容积比较均无明显差异(P>0.05),用药前妊娠组与非妊娠组子宫内膜及内膜下血流相关参数无明显统计学差异(P>0.05),用药后妊娠组RI、PI、ED、PS、VI、VFI降低,S/D、FI升高,差异明显(P<0.05)。用药后子宫内膜及内膜下血流分布类型存在差异(P<0.05),A型血流内膜患者增多。结论 克氯米芬促排卵治疗后对不孕症患者子宫内膜厚度、容积影响不大,三维超声检测克氯米芬治疗后子宫内膜及内膜下血流灌注状况改善的患者,更有助于妊娠。 |
| 关键词: 克氯米芬 不孕症 子宫内膜容受性 三维超声 |
| DOI： |
| 投稿时间：2016-06-21修订日期：2016-06-21 |
| 基金项目:湖北省宜昌市科技研究与开发项目( No:A12301-48) |
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| Assessment of endometrial receptivity using three-dimensional ultrasound in infertile women during treatment with clomiphene |
| yujiaojiao |
| () |
| Abstract: |
| Objective To Evaluate endometrial receptivity by using three-dimensional ultrasound in infertile women during treatment with clomiphene, to explore effects of clomiphene on the outcome of pregnancy and value. Methods：Collected 46 infertile patients from reproductive center treated with clomiphene in the study, as well as the general situation of patients before treatment( age, body mass index, duration of infertility, basic FSH, LH, the number of follicles). Detected endometrial volume, thickness, type, endometrial and subendometrial blood flow parameters (RI, PI, S/D, PS, ED, VI, FI, VFI)by ultrasound and tracked pregnancy outcomes. Patients were divided into pregnant group and non-pregnant group according to the outcome of pregnancy. Results: There was no difference in the general situation before the treatment between pregnant group and non-pregnant group(P>0.05), no difference in endometrial volume and thickness before or after the treatment between the two groups(P>0.05). Before the treatment, endometrial and subendometrial blood flow parameters (RI, PI, S/D, PS, ED, VI, FI, VFI) had no difference between two groups(P>0.05). After the treatment, patients in the pregnant group had lower RI、PI、ED、PS、VI、VFI and higher S/D、FI of blood flow parameters, with statistical significant difference(P<0.05), the type of endometrial and subendometrial blood flow distribution had changed, patients in type A were increased. Conclusions: Clomiphene has little effect on endometrial volume and thickness to infertile women, by using three-dimensional ultrasound, patients with good condition of endometrial and subendometrial blood flow perfusion are helpful to improve the pregnancy rate. |
| Key words: clomiphene,Infertility,endometrial receptivity,three-dimensional ultrasound |
