| 摘要: |
| 目的 通过经颅多普勒（TCD）超声检查，探测阿尔茨海默病（AD）患者脑血流动力学变化及其特点以及该改变与AD患者认知功能受损之间的联系。方法 收集AD患者及认知功能正常的老年人，通过TCD检查，获得两组研究对象颅内动脉的平均血流速度（MFV）及搏动指数（PI）并相互比较。结果 AD组所有颅内动脉的MFV值较对照组减低，PI值较对照组升高。AD组中，简易智能状态检查表评分与MFV呈正相关，与PI呈负相关。所探测动脉血流动力学参数的ROC曲线下面积均大于0.7。结论 颅内动脉MFV降低以及PI升高是AD患者脑血流动 力学的变化特点且改变的程度与认知功能受损的程度相关。TCD不仅对AD具有一定的诊断价值还还具有评估AD患者的治疗效果潜力。 |
| 关键词: 阿尔茨海默,经颅多普勒,脑血流动力学,平均血流速度,搏动指数 |
| DOI： |
| 投稿时间：2016-06-21修订日期：2016-07-07 |
| 基金项目: |
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| Evaluation of cerebral hemodynamic changes of Alzheimer’s disease using transcranial Doppler ultrasound |
| baihetiyatayier,muyuming |
| () |
| Abstract: |
| Objective：Using transcranial Doppler ultrasound(TCD) to evaluate the cerebral hemodynamic changes of Alzheimer’s disease(AD),probe into the relationship between cognition impairment and this changes and diagnosis value of TCD.Methods：AD and non-demented controls were recruited.TCD was employed to assess mean flow velocity (MFV) and pulsatility index(PI) of intracranial arterial segments.Results: MFV in AD group was lower than NDC (P<0.05), while PI in AD group was higher (P<0.05), MFV was positively related to MMSE while PI was negatively correlated toSMMSE in AD group.ROC curves showed that the vast majority of the measurements for PI and MFV in the arteries of interest were significantly different from an ROC area of 0.7. Conclusion:Our study shows that decreased MFV and increased PI was linked to this dementia, TCD and might have a diagnostic potential and TCD may also become instrumental in the efficacy evaluation of drugs and other treatment modalities. |
| Key words: Alzheimer’s disease transcranial Doppler ultrasonography cerebral blood flow mean flow velocity pulsatility index |
