【】Objective To evaluate the clinical value of speckle tracking technique in evaluating the left ventricular twist in children with ventricular septal defect(VSD). Methods Patients with ventricular septal defect (36 cases) as the case group,age and sex matched normal children(36 cases) as the control group,left ventricular end diastolic volumeand end systolic volume and Left ventricular ejection fraction were obtained by real-time three-dimensional echocardiography,two dimensional speckle tracking technique was used to measure the left ventricular twist motion parameters of the two groups to evaluate the clinical value of speckle tracking technique in evaluating the left ventricular twist in children with VSD. Results In the VSD group,the left ventricular basal rotation angle,peak of the left ventricular basal rotation angle,peak of the left ventricular twist angle and torque were significantly greater than that in the control group (P < 0.01) while the apical rotation and peak of the apical rotation angle had no statistical significance (P=0.525、0.757) with the control group.Also,there was no significant correlation between left ventricular twist motion parameters and 3DQA-EDV and 3DQA-EDVI. Conclusions The overload of the left ventricular volume in VSD increase the left ventricular global and basal rotation,the left ventricular twist motion parameters and left ventricular volume had no significant correlation.