ABSTRACT Objective To observe the variation of Energy Loss and Circulation of left ventricular systolic and diastolic periods by vector flow mapping and evaluate the left ventricular systolic and diastolic function in patients with hypertropic cardiomyopathy.Methods Twenty-six non-obstructive hypertropic cardiomyopathy patients（HCM group）and Thirty-six healthy volunteers（control group）were enrolled.The quantitative parameters，including average energy loss（EL-base，EL-mid，EL-apex）and circulation（vortex quantity，vortex area，circulation）were measured in the different periods of VFM imaging mode in an apical four-chamber view，apical three-chamber view and apical two-chamber view respectively.The difference of parameters was evaluated between two groups during early systole，mid-systole，late-systole，early diastole，mid-diastole and atrial contraction period.The early transmitral valve blood flow velocity E，the late transmitral valve blood flow velocity A， the ratio of early transmitral valve blood flow velocity to the early diastolic mitral valve velocity E/e and Tei index was derived via dual-Doppler imaging technology.Meanwhile，correlationship was analyzed between two groups parameters including average energy loss and circulation and E、A、E/e and Tei index，separately.Ressults EL-apex during early diastole，EL-mid during left atrial contraction period，EL-base during early systole and all segments during mid-systole and late-systole there were different between two groups（P＜0.05）；EL decreased gradually from the basal to the apical portion between two groups during six periods that mentioned above（P＜0.01）；The vortex quantity during early diastole and the vortex quantity，vortex area and circulation during mid-diastole were different between two groups（P＜0.05）.The vortex area during early systole and mid-systole was only different between two groups（P＜0.05）；The circulation had positive correlation with E during early diastole for all subjects（r=0.456，P＜0.001）.The circulation had positive correlation with A during left atrial contraction period for all subjects（r=0.485，P＜0.001）.EL-base during mid-systole were negatively correlated with cardiac index for all subjects（r=-0.363，P＜0.01.At the basal and mid segment of atrial contraction period，there were positive correlation between EL and E/e（r=0.31，P＜0.05；r=0.444，P＜0.001），EL and circulation was not corrrlated with tei index.Conclusion EL was increased at all segments of systole，apex segment of early diastole and mid segment of atrial contraction in HCM patients compared with controls .The vortex quantity，vortex area and circulation during diastolic periods and the vortex area during systolic periods were decreased for cases compared with controls .And indeed this values may be a more sensitive parameters for detecting cardiac dysfunction in non-obstructive hypertrophic cardiomyopathy patients than conventional echocardiographic indexes.The new ultrasound technique -Energy Loss and Circulation can serve as new indexs of evaluating early cardiac function by vector flow mapping.