| 摘要: |
| 目的 检测移植肾患者颈总动脉结构参数，初步探讨其形态学变化及影响因素。方法 选取移植肾患者31例（移植肾组），行持续性血液透析且时间与移植肾组患者血液透析累积时间相匹配的终末期肾病患者31例（血液透析组），年龄和性别匹配的正常健康成人84例（对照组）。应用超声射频技术检测并比较各组右颈总动脉内-中膜厚度（CIMT）和右颈总动脉管径（CCAD）；Pearson相关分析CIMT和CCAD的影响因素；多元线性回归分析CIMT和CCAD的独立影响因素。结果 血液透析组患者CIMT为（561.9±147.7）μm，较移植肾组、对照组均增厚[（480.5±90.3）μm、（529.7±131.8）μm ]，差异均有统计学意义（均P＜0.05）；血液透析组患者CCAD为（8.6±0.8）mm，较对照组和移植肾患者均增宽[（7.50±1.0）mm、（7.9±0.8）mm]，差异均有统计学意义（均P＜0.05）。年龄、体重、收缩压及部分血流动力学参数与CIMT和CCAD呈正相关，且是二者的独立影响因素。结论 持续性血透患者肾移植后，其颈总动脉形态学可部分恢复正常；年龄、体重、收缩压及部分血流动力学参数是颈动脉形态学变化的独立影响因素。 |
| 关键词: 超声射频技术 肾移植 终末期肾病 颈动脉 内-中膜厚度 形态学 |
| DOI： |
| 投稿时间：2016-07-04修订日期：2017-01-06 |
| 基金项目: |
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| A Study on morphological structure and risk factors of carotid artery in kidney transplant recipients |
| Li Zhaojun,Du Lianfang |
| (the First People's Hospital Affiliated to Shanghai Jiao Tong University) |
| Abstract: |
| Objective The morphologic properties of carotid artery were analyzed and the related risk factors were preliminarily evaluated in kidney transplant recipients （KTR). Methods Thirty-one KTR(KTR group), 31 patients with end-stage renal disease who supported by hemodialysis and were matched at cumulative time on dialysis to KTR group(hemodialysis group), and age- and sex-matched healthy subjects as controls (control group) were involved in this study. The carotid intima-media thickness（CIMT）and diameter（CCAD）of right carotid arteries were measured by ultrasonic radiofrequency. The risk factors of CIMT and CCAD were analyzed by Pearson correlation analysis; and the independent factors influencing on the CIMT and CCAD were analyzed by multiple linear regression analysis. Results ①Compared with the KTR group [（480.5±90.3）μm] and control group [（529.7±131.8）μm ], hemodialysis group [（561.9±147.7）μm ]had significantly more thickening CIMT(all P＜0.05). ②Compared with KTR group [7.9±0.8）mm] and control group[（7.50±1.0）mm]，hemodialysis group [（8.6±0.8）mm] had significantly wider CCAD(all P＜0.05). ③ Age，weight，SBP and some hemodynamic parameters were positively correlated to CIMT and CCAD, respectively; and they were independent risk factors of CIMT and CCAD, respectively. Conclusion After successful kidney transplantation，the morphologic properties of carotid artery may partly go back to normal. Age，weight，SBP and some hemodynamic parameters contribute to the vascular altered. |
| Key words: Ultrasonic radiofrequency Kidney transplantation End-stage renal disease Carotid artery Intima-media thickness Morphology |
