Objective To assess the value of ultrasound(US), ultrasonography elastosonography(UE) and contrast enhancced ultrasound (CEUS) in the diagnosis and differential diagnosis of Focal fibrosis of the breast (FFB) . Methods Retrospectively comparative analyzed the preoperative ultrasonographic characteristicsresults among 19 FFB, 49 breast invasive ductal carcinoma (IDC) and 34 fibroadenoma (FA) which all confirmed by . Results The average age of FFB was less than IDC group, more than FA group(P＜0.05); The biggest average diameter of the lesions was greater than those of IDC group and FA group(P＜0.05)；The detection rate of the image performances of FFB which performed as boundary is not clear、high echo halo ,rear echo attenuation and inhomogeneous internal echo is similar to IDC group(P＞0.05), higher than the group of FA(P＜0.05)；The detection rate of internal calcification and blood flow signal of FFB is lower than IDC group(P＜0.05)； The average elasticity score of FFB is similar to IDC group(P＞0.05), higher than FA group(P＜0.05)。The image features of CEUS in FFB which performed as lesion with low enhancement 、“into in late, fade late” is commoner see than in IDC group、FA group(P＜0.05)； the sign of twisted large blood vessel in FFB is lower see than that in IDC group(P＜0.05)、FA group(P＜0.05)。 Conclusions The value of the differential diagnosis between FFB and IDC which examed before surgery is limited. CEUS has certain value in the differential diagnosis of FFB, If a little contrast agent entry the suspected mass, strength is lower than the around of normal breast tissue,the twisted large blood vessel in absent , FFB must be in the group of differentia diagnosis.