With the development of ultrasound molecular imaging, liquid perfluorocarbons nanoparticles as new ultrasound molecular probes show good application prospect in the study of targeted ultrasonic molecular imaging and treatment. Liquid perfluorocabons nanoparticles are the very promising ultrasound molecular probes,are expected to realize the ultrasonic molecular imaging technology for accurate diagnoisis and precise treatment of the disease. This article reviews the research advance of liquid perfluorocabons nanoparticles applications of ultrasound molecular targeted imaging and therapy.