Objective：To compare the value of 2D-US and CEUS in differential diagnosis of pancreatic carcinoma and chronic mass pancreatitis,in order to improve the diagnosis before surgery.Methods: Totally 60 patients with pancreatic carcinoma or chronic mass pancreatitis were diagnosised by both 2D and CEUS during Jan 2013 and Dec 2015. To copmare the sensitivity(Sen),specificity(Spe)and enhancement with statistical method.Results: It showed the sensitivity and specificity of CEUS grop were higher than that of 2D grop（P＜0.05）;CEUS showed inhomogeneous enhancement of pancreatic carcinoma were higher than that of chronic mass pancreatitis（P＜0.01） ; AT、TTP of pancreatic carcinoma were longer than that of chronic mass pancreatitis（P＜0.05）;It showed no statistic significant in mTT ;Imax of chronic mass pancreatitis was the same as that of nomal pancreatitis,Imax of pancreatic carcinoma was lower than that of nomal pancreatitis and chronic mass pancreatitis.Conclusion: In contrast to 2D,CEUS could provide objective and effective criterion for differential diagnosis of pancreatic carcinoma and chronic mass pancreatitis．