Objectives：Aimed to identify risk factors influencing clsaaification of frontal horn cysts in neonates. Methods：Clinical data of 224 Neonates with frontal horn cysts, who had underwent both cerebral Ultrasound and MRI examination, were retrospectively analysis. According to the cyst location in ultrasonic image , total 224 frontal horn cysts were divided into three types. Analysis the relationship between the patterns and 6 factors including age, gender, ischemia, haemorrhage , infection and low birth weight. Results：Single factor analysis showed that the factors which associated with frontal horn cysts ultrasound pattern were ischemia（p<0.001）, infection （p<0.001）and low birth weight （p<0.001）. Multiple factor analysis showed that the related factor of each cysts pattern was: ischemia related to Above lateral ventricle（A type）, infection related to Below lateral ventricle（B type） and low weight related to Connatal cysts (C type). Conclusion：Factors included ischemia, infection and low weight respectively influence different types of frontal horn cyst formation, ischemia may be risk factor for A type, infection may be risk factor for B type，and low birth weight may be risk factor for C type.