| 摘要: |
| 目的 探讨盆腔超声对女童中枢性性早熟（CPP）的临床诊断价值。方法 选取因乳腺发育初次就诊的女童219例，以促性腺激素释放激素激发试验阳性（LH峰值＞5 IU/L）为诊断金标准，将患儿分为CPP组128例和单纯性乳腺早发育（PT）组91例，经盆腔超声分别测量并比较两组患儿的子宫和卵巢的长径、前后径、横径、体积，以及最大卵泡直径。对超声测量参数与GnRHa激发试验结果进行相关性分析，绘制受试者工作特征曲线（ROC），根据曲线下面积的大小，判定最佳切割值。结果 CPP组子宫的长径和体积、卵巢的长径和体积，以及最大卵泡直径均显著大于PT组[（2.51±0.43）cm vs.（1.93±0.29）cm，（1.86±1.08）ml vs.（1.06±0.51）ml；（2.58±0.50）cm vs.（2.02±0.51）cm；（1.81±1.09）ml vs.（0.98±0.46）ml；（0.67±0.17）cm vs.（0.21±0.12）cm）]，差异均有统计学意义（均P＜0.05）。CPP组的子宫长度、子宫体积、卵巢长度、卵巢体积及最大卵泡直径与LH峰值均显著相关，其ROC曲线下面积分别为0.70、0.81、0.59、0.63及0.88。结论 经盆腔超声测量子宫卵巢各形态学参数对CPP有一定的诊断价值，其中以子宫体积和最大卵泡直径的诊断价值最高。 |
| 关键词: 超声检查，经盆腔 中枢性性早熟 子宫 卵巢 |
| DOI： |
| 投稿时间：2016-08-22修订日期：2017-01-09 |
| 基金项目: |
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| The Diagnostic Value of Pelvic Ultrasound in Girls with Central Precocious Puberty |
| tangdachuan,luohongchang |
| () |
| Abstract: |
| Objective Evaluate the diagnostic value of the pelvic ultrasound in girls of central precocious puberty（CPP）. Methods 219 cases of girls with early breast development who visited our clinic the first time were selected，the girls were divided into CPP group(128 cases) and simple breast development（premature thelarche，PT 91 cases） group according to the gonadotropin-releasing hormone stimulation test（GnRHa，A peak LH concentration of at least 5 IU/L was classified as CPP）. Morphometric parameters of both groups by pelvic ultrosonography were measured and compared separately：uterine length，width，thickness and volume，ovarian length，width，thickness and volume，diameter of the maximal follicle．Correlation analysis was made between ultrasonic parameters and GnRHa test.The optimum cutoff values were confirmed through area under the receiver operating characteristic curve（ROC）.Results Compared with the PT group ,the uterine length，uterine volume，ovarian length，ovarian volume and the diameter of maximal follicle were significantly larger in the CPP group[（2.51±0.43）cm vs.（1.93±0.29）cm，（1.86±1.08）ml vs.（1.06±0.51）ml；（2.58±0.50）cm vs.（2.02±0.51）cm；（1.81±1.09）ml vs.（0.98±0.46）ml；（0.67±0.17）cm vs.（0.21±0.12）cm）].The difference was statistically significant (P < 0.05) .The morphometric parameters above were significantly associated with LH peak in CPP girls, and no correlation with PT girls.The areas under ROC curve of uterine length，uterine volume，ovarian length，ovarian volume and diameter of maximal follicle respectively were 0.70，0.81，0.59，0.63，0.88 in girls of CPP.Conclusion The pelvic ultrasound parameters are certain valuable in the diagnose of girls with CPP，especially the uterine volume and diameter of maximal follicle. |
| Key words: Ultrasound, The Pelvic Central Precocious Puberty Uterus ovary |
