【】Objective To investigate the relation of hemodynamic parameters of the ductus venosus and liver function in neonates with different gestational age. Methods 175 newborns diagnosed with patent ductus venous were divided into Group A(55 cases, gestational age from 31 to 34 weeks), Group B(58 cases, gestational age from 35 to 37 weeks), Group C(62 cases, gestational age from 38 to 40 weeks) according to the gestational age. The ductus venosus diameter and blood flow velocity of the neonates were detected by color Doppler ultrasound, and the blood flow volume was also calculated. 60 newborns diagnosed with ductus venous closure were chosen as Control group. The changes of liver function indexes [including alanine aminotransferase (ALT) and aspartate transaminase (AST), total bile acid (TBA), blood ammonia (NH3) and serum total protein (TP)] and prothrombin time(PT) were all observed in all groups. Results Group A had significantly higher blood flow volume of ductus venous than Group B and Group C, Group B had higher blood flow volume than Group C, and the differences among the three groups were statistically significant(P<0.01). ALT and AST levels of Group A were higher than those of Group B and Group C, but the differences amoung Group B、Group C and Control group had no statistical significance(P>0.05). TBA、NH3 and PT levels of Group A were higher than those of Group B and Group C, and TP level of GroupA was lower than those of Group B and Group C, and the differences among the three groups were statistically significant(P<0.01), but the differences between Group C and Control group had no statistical significance(P>0.05). Conclusions The blood flow volume of ductus venous got higher with decreasing gestational age in neonates. Besides, the portal vein shunt caused by patent ductus venous in neonates had a certain impact on liver function, and the effect on neonatal liver function was more obvious with the higher blood flow volume of ductus venous.