Now days, cardiovascular disease (CVD) remains one of the leading cause of death in China, its morbidity and mortality is developing year by year. The evaluationSof regional cardiacSfunction (RCF)SinSpatientsSwithSCVD is of great importance for its diagnosis, treatment and prognosis. Strategy to objectively and quantitatively assess the regional cardiac function is critical important. Strain and strain rate (SR) of myocardium can measure tiny deformation of regional myocardium ,offering a more accurate evaluation of RCF and ventricular wall motion. In this review, we summarize the application of strain and SR in cardiovascular diseases in recent years.