ABSTRACT Objective To explore the correlation between the breast parenchyma ultrasound and the age and the application value in the screening of common breast lesions. Methods A total of 400 breast disease in 200patients were investigated by ultrasound. The ultrasonic image patterns were classified according to the tissue structure and involution of breast into glandular，fibro glandular，fibro glandular Type Ⅱ and fatty types. Results The detection rate of the gland body type was in inverse proportion to the age of the subjects (r=-0.534). The rate of fatty type was directly proportional to the age of the patients (r=0.116). Before 50 years of age，the proportion of fibro glandular type Ⅰ was stabilized decreased after 50 years of age. Before 60 years of age，the proportion of fibro glandular Type Ⅱ increased along with an increase of ages with a peak value in groups of 50-59 years，but decreased after 60 years. There was significant difference of the proportion in any age，P＜0.05. Conclusion The age of breast ultrasound classification and the age of the patients were closely related with the age of the patients after non breast surgery, and the rate of degeneration of the terminal duct was faster than that of the age, what should be regarded as the focus of breast disease screening conditions.