Abstract Objective evaluate the clinical value of ultrasonography in the diagnosis of thyroid nodules with calcified lesions. Methods retrospective analysis confirmed by surgery pathology with calcifications of 92 patients with thyroid nodules, benign and malignant thyroid nodule ultrasound imaging parameters analysis, analysis by contrast-enhanced ultrasonography diagnosis of thyroid nodules with calcification of benign and malignant accuracy, specificity and sensitivity. Results the 80.39% of 51 cases were microcalcification, and the proportion of weak enhancement and non-uniform enhancement was 82.35% and 88.24% respectively. Among the 41 benign nodules, 26.83% had microcalcification, and the proportion of weak enhancement and non-uniform enhancement was 9.76% and 14.63% respectively. The ratio of microcalcification, weak enhancement and inhomogeneity of malignant nodules was significantly higher than that of benign nodules, and the difference was statistically significant (χ2= 24.121, 30.024, 30.487, P=0.031,0.020,0.007). The peak intensity of malignant thyroid nodules and benign thyroid nodules was significantly different (P<0.05). However, there was no statistical significance between the time between the two and the peak time (P＞0.05). Two doctors by contrast-enhanced ultrasound diagnosis of benign and malignant calcification in patients with thyroid merger, compared with the pathological analysis, found that the ultrasonic imaging of the calcification of benign and malignant thyroid nodule diagnosis specific degrees, high accuracy and sensitivity, respectively, 82.4%, 83.7%, 86.6%. were microcalcification, and the proportion of weak enhancement and non-uniform enhancement was 82.35% and 88.24% respectively. Among the 41 benign nodules, 26.83% had microcalcification, and the proportion of weak enhancement and non-uniform enhancement was 9.76% and 14.63% respectively. The ratio of microcalcification, weak enhancement and inhomogeneity of malignant nodules was significantly higher than that of benign nodules, and the difference was statistically significant (χ2= 24.121, 30.024, 30.487, P=0.031,0.020,0.007). The peak intensity of malignant thyroid nodules and benign thyroid nodules was significantly different (P<0.05). However, there was no statistical significance between the time between the two and the peak time (P<0.05). Two doctors by contrast-enhanced ultrasound diagnosis of benign and malignant calcification in patients with thyroid merger, compared with the pathological analysis, found that the ultrasonic imaging of the calcification of benign and malignant thyroid nodule diagnosis specific degrees, high accuracy and sensitivity, respectively, 82.4%, 83.7%, 86.6%. Conclusion Ultrasonography has high clinical value and high accuracy in the diagnosis of calcified thyroid nodules.