Objective To discuss the clinical value of wave intensity and high-frequency ultrasonography in evaluation of radial artery wall elasticity and structure in patients of type 2 diabetes mellitus. Methods Ａtotal of 84 patients of T2DM were enrolled and divided into two groups：group A（42 cases，the course ≤10 years）and group B（42 cases，the course ＞10 years ）.And 42 healthy subjects were enrolled as control group. WI was used to measure the elasticity parameters of radial artery in all the groups. And high-frequency ultrasonography was used to measure the intima medial thickness of both sides of the radial artery（rIMT）.The results were analyzed statistically. Results The arterial compliance （AC），accelerating wave intensity （W1） and decelerating wave intensity （W2） in group A and B were significantly lower than those in control group （all P＜0.05）. AC，W1 and W2 in group B were significantly lower than those in group A （all P＜0.05）.The vascular pressure strain elastic modulus （Ep），vascular sclerosis parameters （β） and pulse-wave velocity （PWVβ） in group A and B were significantly higher than those in control group （all P＜0.05）. Ep，β，PWVβ in group B were significantly higher than those in group A （all P＜0.05）.There was no statistical difference of the negative area （NA）among 3 groups.The rIMT in group A and B were significantly higher than that in control group （all P＜0.05） and the rIMT in group B was higher than that in group A （P＜0.05）. Conclusion WI and high-frequency ultrasound can evaluate the elasticity and the structure of radial artery in T2DM patients objectively and non-invasively and have important clinical value.