Objective: To explore the value of routinetransthoracicultrasonography in the diagnosis of mediastinal lymphoma. Methods: The ultrasonographic features of patients with mediastinal lymphoma confirmed by pathology were analyzed retrospectively. The location of lesions, the characteristics of internal echo and the peripheral lymph nodes were observed. The accuracy of ultrasound imaging in diagnosis of mediastinal lymphoma was statistically analyzed. Results: 55 cases of mediastinal lymphoma, with an average age of 27.5 years old. Ultrasonography showed solid mass for all, mass with internal hypoechoic nodules and / or reticular stronger echo accounted for 85.5%; enlarged lymph nodes in around or other parts of the body accounted for 78.2%; 90% of the lesions can be detected bilaterally in the sternum. According to sonographic features, the sensitivity of the diagnosis for mediastinal lymphoma was 85.45 (%) and the specificity was 85.45 (%).The Youden index was 0.79. The consistent rate from different operators was 80.61% and the Kappa value was 0.612. Conclusion: The sonographic findings of mediastinal lymphoma have some characteristics, and the conventional transthoracic echocardiography can be used as an important means for the diagnosis of mediastinal lymphoma.