Objective To investigate the application value of contrast enhanced ultrasound(CEUS) and three-dimensional Color Power Angiography(3D-CPA)in the treatment of radiofrequency for uterine fibroids.Methods 98 cases of patients with uterine fibrods to RFA therapy,Randomly divided into two groups:46 cases of CEUS group and 52 cases of 3D-CPA group,the patients of CEUS group were performed on contrast-enhanced ultrasound before the operation ,recording the degree of enhancement during the peak.The patients of 3D-CPA group were performed on three-dimensional ultrasound,recording fibroids blood flow classification and blood vessels walking,two groups were performed on contrast-enhanced ultrasound after the operation.Compare the differences of the two methods under the guidance of the uterine fibroid of hours postoperatively completed ablation rate and the months postoperatively shrinkage rate. Rusults ①The ascular distribution density of 3D-CPA group and CEUS group. ②Under the guidance of the uterine fibroid ,the differences of completed ablation rate between A group and D group ,B group and E group were no statistically signicant. (P＞0.05) The differences of completed ablation rate between C group and F group were statistically signicant(P＜0.05). ?The months postoperatively shrinkage rate of uterine fibroids in CEUS group was gradual declining,the differences was statistically signicant,as so as 3D-CPA group,but the differences of the two methods in guiding radiofrequency ablation were no statistically signicant respectively(P＞0.05). Conclusion 3D-CPA and CEUS all can better guide has rich blood vessels inside the lesions of fibroids for radiofrequency ablation,but 3D-CPA showed below CEUS of poor blood vessels.Guiding radiofrequency ablation with the two methods respectively,the application value was no difference.