ABSTRACT Objective To observe the hemodynamic changes caused by the stimulation of the peroneal nerve of the lower extremity by dual pulse wave Doppler ultrasonography. Methods Twenty healthy volunteers were included (age 20-40y). The geko T-1 from FirstKind Company was used to stimulate the peroneal nerve, and the HI VISION Ascendus ultrasound instrument was adopted to observe the peak flow velocity and flow volume changes after the stimulation at different time intervals. Results The velocity as well as the flow volume increased significantly in popliteal vein (P<0.05), with the latter reached to the peak 15 minutes after the stimulation. The peak flow velocity and the flow volume did not change significantly for the popliteal artery, but the resistance and the pulsatility index were significantly increased (P<0.05). Conclusion Regularly stimulating of the peroneal nerve could promote the lower extremity circulation, and increase the arterial resistance and the venous return.