Contrast-enhanced ultrasound ( CEUS ) can show microperfusion in newly developed tumors in real time, and is of high value in terms of differential diagnosis of benign and malignant renal tumors. At present, this method is already widely used in the clinical diagnosis of renal tumors. Renal tumors of different pathological types differ in terms of the number, structure and distribution of blood vessels within them. Therefore, by showing differences in blood vessel characteristics between renal tumors of different pathological types, contrast-enhanced ultrasound can distinguish the pathological types of renal tumors, and thereby provide a valuable diagnostic basis to guide precise clinical treatment. This paper summarizes the progress made in research in recent years into contrast-enhanced ultrasound technology in the diagnosis and differentiation of renal tumors, and its clinical applications.