【】 Objective To evaluate the characteristics and its agreement of vasa vasorum angiogenesis of carotid artery in patients with and without cerebral infarction by contrast-enhanced ultrasonography. Methods 47 patients with cerebral infarction and 18 controls were studied by contrast enhanced ultrasonography. The grade of vasa vasorum angiogenesis of carotid artery was analysed and the agreement was studied. Results The grade is always I in the side of infarction in patients with cerebral infarction and there significantly are the differences of the grade of vasa vasorum angiogenesis of carotid artery compared with the side of non-infarction in patients with cerebral infarction and the controls. The grade is always 0 in the side of non-infarction in patients with cerebral infarction and the controls and there are no differences among the above-mentioned three ones. The ratio of cerebral infarction in the grade I was significantly higher than that in the grade 0. The sensitivity and specificity for grade of vasa vasorum angiogenesis of carotid artery ( cutoff value>grade 0) were 72.3％and 61.5％respectively. Interobserver agreement was pretty good. Conclusion There significantly are the differences of the grade of vasa vasorum angiogenesis of carotid artery in patients with cerebral infarction compared with patients with non-cerebral infarction and the grade of vasa vasorum angiogenesis of carotid artery is a valid indicator to anticipate cerebral infarction.