ABSTRACT Objective To investigate the features of focal liver lesions with cirrhosis in contrast-enhanced ultrasound(CEUS). Methods The CEUS features of 53 cases of focal liver lesions with cirrhosis confirmed by aspiration biopsy or surgery were retrospectively enrolled．Fisher''s exact test was used to compare the washout phase differences of hepatocellular carcinoma（HCC） in different degree of differentiation.( high differentiation group and medium-low differentiation group ) and to compare the differences of enhancement patterns of HCC in arterial phase with different size（≤3 cm、3~5 cm、≥5 cm）. Results Among 10 cases of cirrhosis nodule， 7 cases presented iso-enhancing with the surrounding liver parenchyma in the three phases ; 2 cases presented hypo-enhancing in arterial phase and iso-enhancing in portal venous phase and delayed phase; the rest 1 case presented iso-enhancing in arterial phase and portal venous phase and hypo-enhancing in delayed phase. 1 case of cholangiocellular carcinoma presented heterogeneous peripheral enhancement and unconspicuous central enhancement in arterial phase ,and washout occurred in portal venous phase; The washout ratio of HCC in different degree of differentiation in arterial phase 、portal venous phase and late phase have statistical significance （P＜0.05）. There was statistical difference in enhancement patterns between the group（ the diameter≤3cmHCC）and the group（ the diameter≥5cm）（P=0.01＜0.05） . Conclusion There exist phase differences in the washout of hepatocellular carcinoma（HCC） in different degree of differentiation，and there also exist differences in enhancement patterns in arterial phase of HCC with different size. Contrast enhanced ultrasound possesses high specificity in distinguish focal liver lesions with cirrhosis between benign and malignant .