| 摘要: |
| 目的应用三维斑点追踪技术(3D-STI)早期评价阻塞性睡眠呼吸暂停综合征(OSAS)患者左心室整体收缩功能,并探讨其左心室应变与睡眠呼吸暂停程度的关系。方法OSAS患者41例,将其分为轻度组10例、中度组11例、重度组20例,对照组20例。应用常规超声测量室间隔及左室后壁厚度、左室质量指数、左室射血分数等指标,应用3D-STI测量收缩期左室心肌总体长轴应变(GLS)、总体径向应变(GRS)、总体环向应变(GCS)及左室面积应变(GAS),比较各组间差异,分析左心室面积应变参数与心血管危险因素的相关性。结果①重度组 BMI大于对照组；重度及中度组最低SaO2低于其他组,且两组之间亦有差异；各组间AHI差异均有统计学意义(P<0.05)。②室间隔厚度、左室后壁厚度、E/A在病例组和对照组间有差异,重度组E/e’大于其他各组,重度组LVMI大于对照组(P<0.05)③ 病例组GLS、GAS小于对照组,且随病情程度加重呈递减趋势；重度组GRS小于中度组,GCS小于其他各组(P<0.05)④GAS与AHI、BMI呈正相关,与最低 SaO2成负相关。结论1、OSAS患者在LVEF正常的情况下左室心肌收缩功能受损,且受损程度与OSAS的严重程度成正比。2、左室面积应变的受损与 AHI、BMI 、最低 SaO2相关。 |
| 关键词: 阻塞性睡眠呼吸暂停综合征 左心室 三维应变 收缩功能 |
| DOI： |
| 投稿时间：2017-02-26修订日期：2017-02-26 |
| 基金项目: |
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| Evaluation of left ventricular systolic dysfunction in patients with obstructive sleep apnea syndrome by three-dimensional speckle tracking imaging |
| guanyingying,Yang Jun |
| () |
| Abstract: |
| Abstract：Objective evaluation of left ventricular global systolic function in patients with obstructive sleep apnea syndrome(OSAS) with using three dimensional speckle tracking imaging. And explored the relationship between severity of sleep apnea and left ventricular strain.Methods 41 patients diagnosed with OSAS were selected,divided into mild group 10 cases,moderate group11 cases and severe group 20 cases. Another 20 cases as control group. The measurement of ventricular septal thickness,left ventricular posterior wall thickness, left ventricular mass index, left ventricular ejection fraction and other indexes were measured by routine echocardiography, Left ventricular systolic peak strain in different directions including Global longitudinal peak systolic strain (GLS),Global peak radial systolic strain(GRS), Global circumferential peak systolic strain(GCS)and Global area peak systolic strain(GAS)were measured by 3D-STI. Compared with the differences between the groups,the correlation between the left ventricular area strain parameters and cardiovascular risk factors was analyzed. Result ① BMI of the severe OSAS group increased compared with the control group, the minimum SaO2 of severe and moderate group was lower than other groups, and there were also differences between the two groups; AHI differences between the groups were statistically significant.（P<0.05）②The thickness of ventricular septum, posterior wall thickness of the left ventricle, E/A in the case group and the control group were different, the severe group E/e’was greater than the other groups, and the severe group LVMI was greater than the control group (P<0.05). ③The case group GLS and GAS is less than the control group, and with the severity of the disease was decreasing trend. GRS is less than moderate group, GCS is less than the other groups (P<0.05) ④GAS was positively correlated with AHI and BMI, and negatively correlated with the minimum SaO2.Conclusion 1.The left ventricular function of patients diagnosed as OSAS had already impaired even when the LVEF were still normal, and the level of severity of impairment and OSAS was positively related to each other. 2.The damage of left ventricular area strain was related to AHI, BMI and minimum SaO2. |
| Key words: obstructive sleep apnea syndrome left ventricular three-dimensional strain systolic dysfunction |
