Objective To explore changes in common carotid artery elasticity of HBV patients using radio frequency ultrasonography for evaluation of artery function. Methods 40 patients with Hepatitis B virus infection and 34 age- and sex-matched healthy volunteers underwent ARFI imaging and radio frequency ultrasonography. Data and parameters recorded were as follows: ARFI velocity, intima-media thickness(IMT), pulse wave velocity(PWV), distention coefficient(DC), compliance coefficient(CC), stiffness parameter , stiffness parameter and turning point T1(PT1). Results were compared between two groups of study subjects. Results HBV Patients had significantly higher ARFI(2.07±0.67 m/s vs 1.03±0.10 m/s, P<0.001) and IMT(581.8±115.1 um vs 523.4±72.2 um, P<0.05)than the control group. No significant results were found for PWV(7.52±1.71 m/s vs 7.83±1.63 m/s)、CC(0.90±0.37 /kPa vs 0.78±0.30 /kPa)、(5.19±2.48 vs 5.66±2.31),DC, or P(T1) between groups. Conclusion HBV patients have higher ARFI values and increased IMT with no significant changes in functional arterial parameters, indicating that monitoring IMT using radio frequency ultrasonography