Objective：To observe the changes of left ventricular(LV)function in patients with coronary heart disease and heart failure by using two-dimensional(2D)speckle tracking imaging(STI)．Methods：The studied population consisted of 48 patients with heart failure (SEF<50%).48 patients were randomly divided into treatment group (24 cases) and control group (24 cases)．All of the patients receivedS conventionalStherapy for coronary heart disease (CHD). The treatment group was treated by standard daily dose of trimetazidine for 6 months based on the conventionalStherapy . Analysis the change of ventricular contract function before and after treatment by using two-dimensional speckle tracking imaging. Results：The systolic longitudinal strain of the two groups both increased after treatment, andSsignificantlySinStreatmentSgroupSthanSthat of control group ,withSstatisticalSsignificance(P<0．05). Conclusion: Trimetazidine improved Left ventricular contract function in patients with coronary heart disease and heart failure based on conventionalStherapy.