| 摘要: |
| 目的 探讨超声造影评估乳腺癌新辅助化疗疗效的价值。方法收集在我院行乳腺癌新辅助化疗并手术的患者51例,分别于化疗前及手术前行超声造影检查, 评估其化疗前后超声造影指标的变化。结果 超声造影可有效反应肿瘤的化疗效果。化疗前无效组中出现灌注缺损区和放射状血管的概率明显高于有效组(p<0.05)。同无效组相比,有效组多表现为峰值强度低,达峰时间长,区域血流量和血流速度较低(p<0.05)。结论 超声造影对乳腺癌新辅助化疗疗效的预测及评估有一定的临床价值。 |
| 关键词: 超声造影 乳腺癌 新辅助化疗 定量分析 |
| DOI： |
| 投稿时间：2017-03-24修订日期：2017-05-09 |
| 基金项目:国家自然科学基金（No.81571678） 上海市科学技术委员会科研计划项目（No.14411968200） 上海交通大学医学院附属仁济医院横向课题（No.RJKY14-07） |
|
| Neoadjuvant chemotherapy in breast cancer: evaluation of pathologic response with contrast-enhanced ultrasound |
| Wan Caifeng |
| (Department of Medical Ultrasound,Renji Hospital,Shanghai Jiao Tong University school of Medicine) |
| Abstract: |
| ABSTRACT Objective To investigate the value of contrast-enhanced ultrasound (CEUS) in evaluating tumor response to neoadjuvant chemotherapy(NAC) in breast cancer. Methods The study included 51 breast cancer patients who received NAC and surgical treatment. All of the patients underwent CEUS examination before and after NAC. Changes of parameters of the CEUS were evaluated before and after NAC. Results The parameters of CEUS can predict final pathologic response. The area of the perfusion defect and penetrating vessels was more often found in non-response group before NAC than response group (P<0.05). Response group showed significantly lower peak intensity, lower regional blood volume and regional blood flow and higher time to peak than non-response group (P<0.05). Conclusion CEUS is effecting in assessing and predicting the response of breast cancer patients undergoing NAC
KEY WORDS contrast-enhanced ultrasound; breast cancer; neoadjuvant chemotherapy; quantitative analysis |
| Key words: contrast-enhanced ultrasound breast cancer neoadjuvant chemotherapy quantitative analysis |
