[ ] Objective To evaluate the feasibility of Virtual Navigator in the brain of newborns. Method 15 neonates with clinically suspected brain abnormalities,who diagnosed by MRI as normal brains, brain ultrasonography was performed within 24 hours after MRI. Conventional ultrasound scan taken by anterior sagittal images, the lateral fontanel collected by cross-sectional 2D images, select the most satisfactory transverse or sagittal planes, then sonography and MRI images were fused by Virtual Navigator, recorded the fusion time and the success rate. Results All the cases were successfully fused with MRI and ultrasound images, and the success rate was 100%. The time required for fusion were 1-5 minutes with an average of 3 minutes. Conclusion Virtual Navigator can realize the perfect fusion of MRI and conventional ultrasound；The Color Doppler flow imaging can be superimposed on the MRI image, MRI can be used to evaluate the cerebral hemodynamics.So,Virtual Navigator is a new technology with clinical application prospect.