| 摘要: |
| 目的 探讨实时剪切波弹性成像(shear-wave elastography, SWE)评估免疫清除期慢性乙型肝炎患者肝纤维程度与病理结果相关性,为其研究提供可参考依据。方法 对213例免疫清除期慢性肝炎患者进行肝脏弹性模量值测量,以病理结果为金标准,分析免疫清除期慢性乙型肝炎患者肝脏纤维化分期与SWE技术测量结果之间的相关性,采用受试者工作特征曲线(ROC)分析剪切波弹性成像诊断≥ S2 期肝纤维化的效能。结果 肝纤维化 S0、S1、S2、S3～S4 期的弹性模量值分别为(6.73±2.04)kPa、(7.06±2.60)kPa、(88.34±4.12) kPa、 (12.82±6.63)kPa, 组间比较差异有统计学意义 (F=22.141,P<0.01)。SWE技术诊断显著肝纤维化 (≥ S2 期)的 ROC 曲线下面积为0.739,阈值为8.81 kPa,对应的敏感度与特异度分别为58.8%、81.9%。结论 SWE技术为诊断免疫清除期慢性乙型肝炎患者肝纤维化分期提供参考依据,为进一步治疗及预后提供一定帮助。 |
| 关键词: 超声剪切波弹性成像 免疫清除期 慢性乙型肝炎 |
| DOI： |
| 投稿时间：2017-04-06修订日期：2017-05-15 |
| 基金项目: |
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| Study on the correlation of liver elasticity imaging in patients with chronic hepatitis B during immune clearance |
| shan yan,Han Liqun |
| () |
| Abstract: |
| Objective To investigate the correlation between the degree of hepatic fibrosis and the pathological results in patients with shear-wave elastography (SWE) during the immune clearance phase by real-time elastography (shear-wave), To provide a reference for the study. Methods In 213 cases of immune clearance phase in patients with chronic hepatitis liver elastic modulus measurement, with pathological results as the gold standard to analyze the correlation between the immune clearance phase of liver fibrosis in patients with chronic hepatitis B and SWE measurements, the receiver operating characteristic (ROC) shear wave elastography in the diagnosis of liver fibrosis in the performance of ≥S2 analysis of curve. ROC analysis of shear wave elasticity imaging in the diagnosis of ≥ S2 stage of liver fibrosis. Results The elastic modulus of S0, S1, S2and S3～S4 of liver fibrosis phase respectively is (6.73 ± 2.04), kPa (7.06 ± 2.60), kPa (88.34 ± 4.12), kPa (12.82 ± 6.63) kPa, there were significant differences between the groups (F=22.141, P<0.01). SWE in the diagnosis of significant fibrosis (≥ S2) of the area under the ROC curve was 0.739, the threshold is 8.81 kPa, corresponding to the sensitivity and specificity were 58.8% and 81.9%.Conclusion SWE technology provides a reference for the diagnosis of liver fibrosis stage in patients with chronic hepatitis B, and provides some help for further treatment and prognosis. |
| Key words: Shear-wave elasticity imaging techniques During the immune clearance phase Chronic hepatitis b |
