【S】objective:To discuss the curative effect of high intensity focused ultrasound ablation(HIFU) for the treatment in uterine incision scar pregnancy.Methods: 100 patients with uterine incision scar pregnancy were selected from December 2012 to December 2015 in our Hospital, according to the treatment method, all patients were divided into HIFU group and electric cut group, 50 cases in each group,electric cut group was given methotrexate combined hysteroscopic surgery treatment, HIFU group on the basis was given HIFU surgery treatment,statistical analysis of all patients with intraoperative blood loss, surgery, human chorionic gonadotropin(beta-hCG) often, menstrual recovery time, complication, 1 year pregnancy outcomes and preoperative,postoperative blood beta hCG levels.Results:The intraoperative blood loss, beta hCG often, menstrual recovery time, complications and recurrence rate of HIFU group were significantly lower than those of electric cut group,the again normal pregnancy rate of the former was significantly higher than that of the latter, the difference was statistically significant (P < 0.05), but the operation time of two groups were basically the same,here was no statistically significant difference (P > 0.05).Compared with preoperative,the postoperative blood beta hCG levels of HIFU group and electric cut group were decline,but the 7 d postoperative blood beta hCG level of the former was significantly lower than that of the latter, the difference was statistically significant (P < 0.05).Conclusions:In the methotrexate combine hysteroscopic surgery, combine HIFU has good curative effect in uterine incision scar pregnancy, which can effectively reduce the surgical trauma and complication of patients,it is helpful to improve the pregnancy outcome within 1 year.