| 摘要: |
| 目的 探讨甲状腺乳头状癌（PTC）超声造影定量参数与病理微血管密度（MVD）的相关性。方法 回顾性分析33例PTC患者（共36枚结节）术前常规超声及超声造影检查的声像图资料。应用Qlab软件绘制结节边缘及中心区域时间-强度曲线（TIC），获得不同部位的超声造影定量参数值，包括峰值强度和曲线下面积；术后对标本均进行CD31因子免疫组化染色，并分别计算结节边缘区域及中心区域的MVD，并分析上述超声造影定量参数与MVD的相关性。结果 PTC结节整体呈不均匀低增强，结节边缘区域增强程度多高于中心区域。PTC结节边缘区域RT、PI、AUC及MVD分别为（3.24±2.10sec、7.84±2.55dB、182.63±87.83dB sec、35.09±9.61条/HP），均高于结节中心（2.42±1.93sec、4.01±2.36dB、89.90±54.67dB sec、15.97±6.07条/HP），差异均有统计学意义（均P＜0.05）。PTC结节边缘区域的峰值强度和曲线下面积与边缘区域MVD均呈正相关（r= 0.831，P=0.000；r= 0.705，P=0.000）；PTC结节中心区域的峰值强度和曲线下面积与中心区域MVD之间均呈正相关（r= 0.678，P=0.000；r= 0.684，P=0.000）。结论 PTC结节的超声造影定量参数峰值强度和曲线下面积能反映PTC不同部位组织的MVD，CEUS可作为术前评估PTC结节MVD的无创性方法。 |
| 关键词: 超声检查 造影剂 甲状腺乳头状癌 微血管密度 CD31 |
| DOI： |
| 投稿时间：2017-05-21修订日期：2018-01-02 |
| 基金项目: |
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| Correlation of Contrast-enhanced ultrasonographic quantitative parameters with Microvessel density in Papillary Thyroid cacinomas |
| chenghong,Qitingyue |
| () |
| Abstract: |
| Objective To investigate the correlation of contrast-enhanced ultrasonographic（CEUS） quantitative parameter with microvessel density（MVD） in papillary thyroid carcinomas（PTC）.Methods We retrospectively analyzed 36 PTCs of 33 patients，which underwent preoperative conventional ultrasound and Contrast-enhanced ultrasonography（CEUS） . Qlab software was applied to draw and analyze the nodules，then obtained quantitative parameters of CEUS from different parts. Thyroid tumors''s specimens were stained with CD31 antibodies in postoperation，and MVD was calculated based on nodules'' edge and central regions. Then the relationship between quantitative feature and the level of MVD was analyzed using SSPS 22.0 sofrware. Result：The contrast-enhancement patterns of the majority of the whole lesions was hypo-enhancement. Enhancement degree in nodal brim region was much higher than in the center region. The RT、PI、AUC and MVD of CEUS of nodal brim region were 3.24±2.10sec、7.84±2.55dB、182.63±87.83dB sec、35.09±9.61twigs/HP respectively,and higher than the nodal center region which were 2.42±1.93sec、4.01±2.36dB、89.90±54.67dB sec、15.97±6.07twigs/HP respectively，and differences were statistically significant（P＜0.05）. A significantly positive correlation was observed between peak intensity（PI） and the area under the curve（AUC） of CEUS and MVD in PTC nodal brim region tissues（rPI= 0.831，P=0.000、rAUC= 0. 705，P=0.000）; A positive correlation was observed between PI and AUC of CEUS and MVD in PTC nodal center area tissues（rPI= 0.678，P=0.000、rAUC= 0. 684，P=0.000）. Conclusion：The PI and AUC of CEUS could reflect the MVD in PTC tissues. Therefore,we can use CEUS as a noninvasive method to assess MVD in preoperative PTC tissues. |
| Key words: Ultrasonic Examination Contrast Agent Papillary Thyroid Cacinoma Microvessel Density CD31 |
