| 摘要: |
| 目的：分析剪切波弹性成像技术评价急性缺血性脑卒中患者颈动脉硬度的可行性。方法：以153例首发急性缺血性脑卒中患者为观察组,同期150例健康自愿者对照组。收集所有受试者的一般资料；应用超声测量双侧颈动脉脉搏波传导速度(PWV)；应用实时剪切波弹性成像(SWE)技术测量双侧颈动脉的纵向平均弹性模量的平均值(MEmean)、最大弹性模量的平均值(MEmax)以及最小弹性模量的平均值(MEmin)。分析两组受试者的相关指标,对受试者的PWV值和MEmean值进行相关性分析,绘制ROC曲线评估PWV和MEmean在预测急性缺血性脑卒中方面的价值。结果：与对照组比,观察组的体重指数(BMI)、收缩压、舒张压、甘油三脂(TG)、低密度脂蛋白(LDL-C)、空腹血糖、颈动脉内-中膜厚度(CIMT)、血管弹性系数(EP)、PWV、 MEmean 、MEmax值及高血压、糖尿病患者的例数均明显升高,而观察组的高密度脂蛋白(HDL-C)、血管顺应性(AC)值降低,差异均有统计学意义(P<0.05)。PWV值和MEmean值呈正相关(r=0.651,p=0.000)。PWV、MEmean预测急性缺血性脑卒中的ROC曲线下面积及P值分别为：AUC=0.846,P=0.000；AUC=0.805,P=0.000。结论：SWE能有效的评估急性缺血性脑卒中患者颈动脉的僵硬度,且对急性缺血性脑卒中有一定的预测价值。 |
| 关键词: 剪切波弹性成像 急性缺血性脑卒中 脉搏波传播速度 颈动脉僵硬度 |
| DOI： |
| 投稿时间：2017-06-15修订日期：2017-07-27 |
| 基金项目:宁波市鄞州区科技计划项目（2015-96） |
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| Analysis of the feasibility of shear wave elastography in evaluating carotid artery stiffness in patients with acute ischemic strokeWU Meng1, ZHOU Ru-Hai1, LI Liang-Da2 |
| WU Meng |
| (Department of ultrasonic medicine, Yinzhou People's Hospital, Ningbo City, Zhejiang Province) |
| Abstract: |
| Objective To analyze the feasibility of shear wave elastography in evaluating carotid artery stiffness in patients with acute ischemic stroke. Methods One hundred and fifty-three patients with acute ischemic stroke were involved as the observation group. One hundred and fifty healthy volunteers were involved as the control group. General information were collected from all subjects. Carotid pulse wave velocity (PWV) measured by ultrasound. The average values of longitudinal average elastic modulus (MEmean), the maximum elastic modulus (MEmax ) and minimum elastic modulus (MEmin ) were calculated by SWE of bilateral carotid artery. The related indexes of two groups were analyzed. The correlation between PWV and MEmean was analyzed. The ROC curve was used to evaluate the prognostic value of PWV and MEmean in patients with acute ischemic stroke. Results Compared with the control group, the Body mass index (BMI), systolic blood pressure, diastolic blood pressure, glycerol three fat (TG), low density lipoprotein (LDL-C), fasting plasma glucose, carotid artery medial thickness (CIMT), vascular elasticity coefficient (EP), PWV, MEmean, MEmax value and the number of patients with hypertension, diabetic patients of observation group were significantly increased, while the high density lipoprotein (HDL-C), vascular compliance (AC) value of observation group were decreased, the differences were statistically significant(P<0.05).PWV was positively correlated with MEmean (r=0.652,0.557, p=0.000,0.000).The area under the ROC curve and P value of PWV and MEmean predict of acute ischemic stroke were AUC=0.846,P=0.000; AUC=0.805, P=0.000.Conclusion SWE can be used to evaluate carotid artery stiffness in patients with acute ischemic stroke, and it has some predictive value for acute ischemic stroke. |
| Key words: Shear wave elasticity imaging techniques, Acute ischemic stroke, Pulse wavevelocity, Carotid Arterial stiffness. |
