| 摘要: |
| 【摘要】目的 探讨胎儿颈项透明层（NT）增厚与胎儿异常妊娠的关系，评估其在胎儿预后中的价值。方法 回顾性分析2014年7月至2016年7月早孕期我院筛查的584例NT增厚的单胎胎儿病例，按照不同NT值分为3.0-3.9mm、4.0-4.9 mm 及≥5.0 mm 3组，计算每组胎儿结构异常、染色体异常、不良预后的发生率，分析NT增厚与异常妊娠的关系。结果 （1）超声检查发现胎儿NT增厚发生率1.85%，其中单纯NT增厚者56.51%，合并其他结构异常者占43.49%。（2）419例胎儿行染色体核型分析，结果显示核型正常364例，核型异常55例。（3）正常分娩存活283例，自然流产或胚胎宫内停止生长15例，引产282例，失访4例。（4）结果显示：NT增厚时胎儿结构异常、不良预后发生率与胎儿NT不同厚度之间存在明显差异，差异具有统计学意义（x2值分别为3.464、37.312，P值分别为0.019、0.000）。而染色体异常发生率与胎儿NT不同厚度之间差异不显著（P>0.05）。结论 胎儿NT增厚与胎儿异常妊娠密切相关，且胎儿异常妊娠发生率随NT增厚明显升高，因此NT增厚是有效的产前筛查指标。 |
| 关键词: 超声 胎儿颈项透明层（NT） 胎儿 异常妊娠 |
| DOI： |
| 投稿时间：2017-06-16修订日期：2017-06-23 |
| 基金项目: |
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| Assessment the Clinical Value of Nuchal Translucency（NT）Thickness in the Early Pregnancy |
| Hou Li |
| () |
| Abstract: |
| 【Abstract】 Objective To investigate the correlation between Fetuses NT’s thickness values and their abnormal pregnancy, and further evaluate measurement of NT’s application in fetal prognosis. Methods 1) Collect the sample of 584 prenatal ultrasonography fetuses with NT thickening observation (3mm in week 11-13+6) from July 2014 to July 2016; 2) Segment the NT cases by different NT values (3.0 -3.9mm, 4.0 -4.9mm, ≥5mm) and calculate the abnormal fetal structural ratio, chromosome abnormalities ratio and poor prognosis incidences in segments; 3) Analyze and test statistically the relationship between fetuses NT thickness and their abnormal pregnancy ratio. Results 1) Ultrasonography finds that 1.85% fetuses have the abnormal NT value (≥3), which turn out to be 56.51% normal and 43.49% abnormal (structural abnormalities all-inclusive) fetuses; 2) The chromosome core type analysis on the 419 fetuses with NT>3 illustrates, 364 turn out to be normal while as high as 55 cases have karyotype abnormalities; 3) Survival comparison analysis on the delivery illustrate: the distribution of the 584 cases with NT≥3 is that normal pregnancy accounts for 283, abortion/intrauterine stopped-growth accounts for 15, induced labor cases account for 282 and follow-up loss cases account for 4; 4) Statistical test results further demonstrate: there is significant difference of abnormal fetal structural ratio (with Chi-square value of 3.464 and according P-value of 0.019) and poor prognosis incidences (with Chi-square value of 37.312 and according P-value of 0.000) among different segments of high NT values. However, there is NO strong correlation statistically between high NT value and chromosome abnormalities ratio. Conclusion NT thickness value has high correlation with abnormal pregnancy ratio and the ratio increases significantly along with the higher NT values. Thus NT thickness values can serve as an effective indicator in prenatal screening. |
| Key words: Ultrasound Nuchal Translucency (NT) Fetus Abnormal Pregnancy |
