| 摘要: |
| 摘 要 目的 探讨分层应变技术在评价蒽环类化疗药物对乳腺癌患者左心室心肌纵向收缩功能影响中的价值。方法 选取60例乳腺癌术后蒽环类化疗的女性患者，在化疗前、第2、4、6个周期化疗后（LS0、LSI、LSII、LSIII）四个阶段分别采集每位患者左心室心尖位二腔、四腔切面、左心室长轴切面二维图像，并测定常规超声参数及心内膜下、中层和心外膜下心肌的纵向应变（LS）峰值。结果 化疗各阶段间常规超声心动图参数差异无统计学意义(P > 0.05)。化疗各阶段中不同节段间心肌的LS[所有应变均有方向性，因此应该是绝对值比较，注意全文修改][老师说的非常对。所测得应变数据均为负值，原表格数据未进行改动。因分析都是绝对值的比较，所以在统计学处理中加上了“LS的数值比较均为绝对值的比较”此句话。]均由内向外逐层递减，差异有统计学意义(P < 0.05)。各节段心内膜层LS随化疗周期的增加逐渐减低，其中LSIII组心内膜层LS最低，除LSI与LS0外，余各节段不同化疗周期心内膜下心肌比较差异均有统计学意义(P < 0.05)。 |
| 关键词: 斑点追踪成像 分层应变 蒽环类 心脏毒学类 心室功能 |
| DOI： |
| 投稿时间：2017-06-18修订日期：2017-11-24 |
| 基金项目: |
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| Layer-specific Strain Technology in Evaluation of Effect of Anthracycline-induced Cardiotoxity on Left Ventricular myocardial strain in Breast Cancer Patients |
| He Xuan,Chen Dongfeng |
| (Affiliated Hospital of Jining Medical University) |
| Abstract: |
| [Abstract] Objective To evaluate the effect of anthracycline-induced cardiotoxity on left ventricular longitudinal systolic function by layer-specific strain technology in patients with breast cancer.Methods Sixty cases of breast cancer women patients using anthracycline-based chemotherapy were included, according to the different cycles of chemotherapy,the process were divided into four stages：the basic status before chemotherapy（LS0）,the second chemotherapy cycle（LSI）,the fourth chemotherapy cycle（LSII） and the sixth chemotherapy cycle（LSIII）.Two dimensional images were recorded from the apical four-chamber view,two-chamber view and long-axis view of the left ventricle during three consecutive cardiac cycles.Peak systolic longitudinal strain(LS)were measured in sub-endocardium,midmyocardium and subepicardium.Results The conventional echcardio graphic parameters had no significantly difference among the four stages(P > 0.05).In the four stages of chemotherapy cycle,LS of subendocardium was the highest,and subepicardium was the lowest(P < 0.05).LS of three views of endomyocardial in different stages had significant difference (P < 0.05) and they were reduced in the chemotherapy process,LSIII was the lowest. The difference of endomyocardial LS in different chemotherapy process all showed statistical significance(P < 0.05),but the difference between LSI and LS0 has no statistical significance.(P > 0.05).Conclusion The change of left ventricular myocardium longitudinal function in patients with breast cancer can be valued by the layer-specific strain technology,and the mainly dysfunction is in the subendocardium. |
| Key words: Speckle tracking imaging layer-specific strain Athracyclines Cardiotoxins Ventricular function |
