| 摘要: |
| 目前,已有许多药物对脑部疾病的治疗具有显著作用,但由于血脑屏障的存在限制了药物在临床应用中的治疗效果。聚焦超声联合微泡技术是一种安全、高效的开放血脑屏障技术,能有效递送药物进入大脑,从而提高药物的疗效。本文介绍了血脑屏障的分子结构与转运功能,阐述了影响药物入脑递送的主要因素和相关的解决方法,分析了超声开放血脑屏障的安全性和主要机制,讨论了超声介导药物递送在临床治疗中的应用。 |
| 关键词: 超声 血脑屏障 药物入脑 |
| DOI： |
| 投稿时间：2017-07-01修订日期：2017-07-31 |
| 基金项目: |
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| Using FUS induced BBB opening and drug delivery into the brain |
| ZHU Shu-ting |
| (School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou) |
| Abstract: |
| : Though many active chemotherapeutics have been developed, they are not suitable for the treatment of brain diseases because of the blood-brain barrier(BBB), which limiting the therapeutic effect of the drug in clinical applications. The technique referred as ultrasound-targeted microbubble destruction (UTMD) can lead to non-invasive and reversible BBB disruption, thus improving the efficiency of drug delivery across biological barriers. This paper introduces the molecular structure and transport function of the blood-brain barrier, besides elaborates the influencing factors and related countermeasures which can realize the delivery of transporting the drugs into the brain, furthermore analyzes the deep mechanism and the safety of the disruption of blood-brain barrier in the pattern of ultrasound, finally, discusses the application of the ultrasound-mediated drugs delivery in clinical treatment. |
| Key words: : ultrasound blood-brain drug brain delivery |
