| 摘要: |
| 目的 利用动物模型观察双侧颈总动脉结扎后基底动脉的重构。 方法 健康新西兰大白兔20只，利用彩色多普勒超声分别于术前、术后即刻，术后2天、7天、30天观察实验兔基底动脉的走行，测量其内径（D），记录基底动脉的血流动力学参数，包括收缩期峰值流速（Vs）、舒张末期流速（Vd）、平均速度（Vm）、RI（阻力指数）、PI（搏动指数），计算血流量（Q）。 结果 双侧颈总动脉结扎后，基底动脉血流量增多，术后2天达到峰值；走行扭曲，扭曲程度随时间的延长逐渐加重；术后30天内径明显增宽，与术前比较，差异具有统计学意义（P＜0.01）；术后2天Vs、Vd、Vm到达峰值，随后开始逐渐减慢。结论 双侧颈总动脉结扎后基底动脉血流量增加导致基底动脉扩张重构。血流量的改变会快速的导致形态学的改变，不需要长期影响实质性重要结构而发生变化。另外，重构的发生往往出现在血流量增加的阈值范围内，超过阈值则会导致明显的弯曲重构。 |
| 关键词: 基底动脉 颈动脉结扎 重构 兔 |
| DOI： |
| 投稿时间：2017-08-01修订日期：2017-12-26 |
| 基金项目: |
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| Assessment of rabbits’ basilar artery remodeling following common carotid artery ligation by Color-coded Doppler Ultrasonography |
| caohui |
| (Department of Ultrasound, Yueyang Hospital of Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine) |
| Abstract: |
| ABSTRACT Objective We observed the remodeling of basilar artery（BA）following common carotid artery(CCA) ligation in animal model we made. Methods Twenty healthy white rabbits which bilateral CCA were ligatured. The BA of rabbits were examined before operation, at the immediate，2 days, 7 days, 30 days after operation respectively by Color-coded Doppler Ultrasonography. The shape and course of BA were observed, the diameters(D) of BA were measured, the hemodynamic parameters such as systole peak velocity(Vs), diastole velocity(Vd), mean velocity(Vm), the pulsatility index(PI) and resistance index(RI) were recorded, BA flow(Q) were computed according to the equation. Results After bilateral carotid artery ligation, the flow of basilar artery increased and reached a peak at the 2th day after operation, the shape of basilar artery twisted and became severely with time, the diameter of basilar artery widened significantly at the 30th day after operation, compared with that before operation (P < 0.01). Vs, Vd, and Vm reached a peak at the 2th day after surgery, then began to slow down gradually. Conclusions Increased BA flow results in adaptive BA remodeling following bilateral CCA ligation. Morphological changes occur rapidly following flow alteration and do not require chronic insult to affect substantial and significant structural transformation. Additionally, it appears that there exists a flow-increase threshold, when surpassed, results in significant tortuosity. |
| Key words: Basilar artery Carotid artery ligation remodeling Rabbit. |
