| 摘要: |
| 目的 应用超声造影(CEUS)检测急性脑梗死患者颈动脉斑块内新生血管定量指标,初步探讨其与血压的相关性。方法 急性缺血性大动脉粥样硬化性脑梗(LAAS)患者62例。年龄、性别匹配对照组54例。选取颈动脉优势斑块行CEUS,脱机定量分析获取斑块强度均值(TIC-M)、拟合曲线峰值(FC-P)和曲线下面积(FC-AUC)。采用Pearson相关分析诸参数与血压的相关性。结果 ①收缩压和舒张压在两组间差异无统计学意义(P＞0.05)。②在脑梗组,患者颈动脉斑块造影参数TIC-M、PC-P和FC-AUC均大于对照组(P＜0.05)。③TIC-M与收缩压和舒张压呈负相关(r=-0.582和r=-0.681,P均＜0.05)。FC-P与收缩压和舒张压呈负相关(r=-0.585和r=-0.690,P均＜0.05)。FC-AUC与舒张压呈负相关(r=0.493,P＜0.05)。结论 颈动脉斑块内新生血管的CEUS定量指标与血压密切相关,CEUS评估易损斑块应考虑血压的影响。 |
| 关键词: 超声造影 脑梗死 颈动脉 斑块 血压 |
| DOI： |
| 投稿时间：2017-08-04修订日期：2018-06-16 |
| 基金项目:上海市科学技术委员会医学引导类科技项目（15411969100,16411969300）；上海交通大学医工交叉研究基金（YG2015MS28）；上海市卫生和计划生育委员会基金(201440290,201640043）；促进市级医院临床技能与临床创新能力三年行动计划（16CR3105B）；上海交通大学医学院科技处技术转移推广项目（ZT201710，ZT201711） |
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| Correlation between carotid plaque parameters of CEUS and blood pressure in patients with acute stroke |
| LI Zhao-jun,LUO Xiang-hong. |
| (Shanghai General Hospital, Shanghai Jiaotong University) |
| Abstract: |
| Objective To detected the neovascularizations in carotid plaques using contrast-enhanced ultrasound (CEUS), and to explore the relationship between neovascularizations and blood pressure. Methods Sixty-two patients with large artery atherosclerosis stroke (LAAS) and 54 age-and gender-matched control subjects were recruited. The dominant carotid artery plaques were imaged by CEUS. The mean of time-intensity curve (TIC-M), the peak (FC-TP) and area under the curve (FC-AUC) obtained from fitting curves were analyzed off-line. The correlations between parameters of contrast-enhanced ultrasound and blood pressure were analyzed by Pearson correlation analysis. Results ①Systolic and diastolic blood pressure were no significant difference between the two groups (P> 0.05). ②TIC-M, FC-P and FC-AUC were significantly higher in the LAAS group than in the control group (P <0.05). ③ TIC-M was negatively correlated with systolic and diastolic blood pressure, respectively(r=-0.582 and r=-0.681,all P＜0.05). FC-P was also negatively correlated with systolic and diastolic blood pressure, respectively(r=-0.585 and r=-0.690,all P＜0.05). FC-AUC showed a negative correlation with diastolic blood pressure(r=0.493,P＜0.05). Conclusion The parameters of neovascularizations in carotid plaques were closely related to blood pressure. Therefore, the effects of blood pressure should be considered when vulnerable plaques were assessed by CEUS. |
| Key words: Contrast-enhanced ultrasound Stroke Carotid artery Plaque Blood pressure |
