Objective To detected the neovascularizations in carotid plaques using contrast-enhanced ultrasound (CEUS), and to explore the relationship between neovascularizations and blood pressure. Methods Sixty-two patients with large artery atherosclerosis stroke (LAAS) and 54 age-and gender-matched control subjects were recruited. The dominant carotid artery plaques were imaged by CEUS. The mean of time-intensity curve (TIC-M), the peak (FC-TP) and area under the curve (FC-AUC) obtained from fitting curves were analyzed off-line. The correlations between parameters of contrast-enhanced ultrasound and blood pressure were analyzed by Pearson correlation analysis. Results ①Systolic and diastolic blood pressure were no significant difference between the two groups (P> 0.05). ②TIC-M, FC-P and FC-AUC were significantly higher in the LAAS group than in the control group (P <0.05). ③ TIC-M was negatively correlated with systolic and diastolic blood pressure, respectively(r=-0.582 and r=-0.681,all P＜0.05). FC-P was also negatively correlated with systolic and diastolic blood pressure, respectively(r=-0.585 and r=-0.690,all P＜0.05). FC-AUC showed a negative correlation with diastolic blood pressure(r=0.493,P＜0.05). Conclusion The parameters of neovascularizations in carotid plaques were closely related to blood pressure. Therefore, the effects of blood pressure should be considered when vulnerable plaques were assessed by CEUS.