Objective To assess the diagnostic value of the technology of Shear-Wave Elasticity (SWE) in early diagnosis of chronic kidney disease (CKD). Methods Shear-Wave Elasticity imaging were performed in 30 patients with CKD confirmed by biopsy and 30 healthy objects. We got the quantitative elasticity value (Young’s modulus) by SWE in the left kidney cortex, medullary and sinus, and compared. Results 1.The comparison of elasticity value: ① In the control group, the Emax and Emean of cortex was(3.47±0.54) kPa and(1.87±0.68)kpa, the Emax and Emean of medullary was (2.45±1.09) kPa and (1.08±0.68)kpa, the Emax and Emean of sinus was( 9.01±3.74) kPa and (7.49±2.77) kPa, with statistically significant difference(P＜0.01). In the patient group, the Emax and Emean of cortex was(4.12±1.71)kPa and(2.76±1.06)kpa, the Emax and Emean of medullary was (2.57±1.07) kPa and(1.27±0.68)kpa, the Emax and Emean of sinus was(8.76±2.45) kPa and(6.78±2.57)kPa, with statistically significant difference(P＜0.05).②Comparison the data between the control group and the patient group, the data of Emax and Emean in patient group were significantly greater than the data in the control group, especially the Emean of cortex(P＜0.01). 2. Evaluation the reliability of the elasticity value (Young’s modulus) in diagnosis the CKD by ROC curve: the AUROC of the cortex value＞0.7, and with fine accuracy and specificity by the cut-off point 3.15kpa. Conclusion Shear-wave ultrasound elasticity imaging can provide quantitative elasticity value of the different part of the kidney, and closely related to the lesion position and degree. SWE with quantitative value can provide more assistance in evaluation kidney elasticity for clinical diagnosis in CKD.