| 摘要: |
| 【摘要】目的：应用超声心动图定量评价慢性肾脏病(CKD)患者左心室结构与功能的改变情况。方法：以2015年2月-2017年1月我院收治的131例CKD患者为研究对象，按照GFR水平将131例CKD分为CKD2-3组(n=68)与CKD4-5组(n=63)，同时以同期的60例正常者为对照组。采用超声心动图技术获得三组的左心室结构参数[左心室的质量(LVM)、质量指数(LVMI)、相对室壁厚度(RWT)]及功能参数[左心室射血分数(LVEF)、二尖瓣舒张早期血流速度(E)、二尖瓣舒张早期血流速度(A)、二尖瓣环舒张早期运动速度(Em)、E/A、E/Em]，比较三组的左心室结构及功能参数、并对RWT与E/Em的影响因素及相关性进行分析。结果：CKD4-5组出现左心室结构改变53例(84.1%)，CKD2-3组出现左心室结构改变19例(27.9%)，两组比较差异具有统计学意义(P<0.05)；CKD2-3组LVM、LVMI、RWT均明显高于对照组(P<0.05)，CKD4-5组LVM、LVMI、RWT、A、E/Em均明显高于CKD2-3组与对照组(P<0.05)，Em、DTE、E/A均明显低于CKD2-3组与对照组(P<0.05)；PWVcF、eGFR是RWT的独立相关因素，PWVcF、RWT是E/Em的独立相关因素。结论：左心室结构改变发生在CKD患者早期，功能改变发生在晚期，且改变明显；左心室结构及功能的改变与动脉僵硬度密切相关。 |
| 关键词: 【关键词】慢性肾脏病(CKD) 超声心动图 左心室 结构 功能 定量评价 |
| DOI： |
| 投稿时间：2017-08-08修订日期：2018-10-10 |
| 基金项目: |
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| Quantitative evaluation of left ventricular configuration and function in patients with chronic kidney disease(CKD) by ultrasonic cardiogram |
| pengshan |
| () |
| Abstract: |
| Abstract: Objective To quantitatively evaluate of change of left ventricular configuration and function in patients with chronic kidney disease(CKD) by ultrasonic cardiogram. Methods 131 cases of CKD patients were divided into CKD2-3 group(n=68) and CKD2-3 group(n=63) according to the level of GFR in our hospital during 2015.2～2017.1. 60 cases of normal subjects were control group at the same time. The structural parameters[left ventricular mass(LVM), left ventricular mass index(LVMI),relative wall thickness(RWT)] and functional parameter[left ventricular ejection fraction(LVEF),E,A,Em,E/A,E/Em] of left ventriculus sinister was acquired by ultrasonic cardiogram and was compared. The influence factors and correlation of RWTand E/Em was analyzed. Results 53(84.1%) CKD patients had change of left ventricular configuration in CKD4-5 group, 19(27.9%) CKD patients had change of left ventricular configuration in CKD2-3 group, there was statistically significant difference between two groups(P<0.05). The LVM,LVMI,RWT of CKD2-3 group was significantly higher than control group(P<0.05), the LVM,LVMI,RWT,A,E/Em of CKD4-5 group was significantly higher than CKD2-3 group and control group(P<0.05), the Em,DTE,E/A of CKD4-5 group was significantly lower than CKD2-3 group and control group(P<0.05). PWVcF and eGFR was the independent relevant factor of RWT, PWVcF and RWT was the independent relevant factor of E/Em. Conclusion Left ventricular configuration was changed in the early phase of CKD patients and left ventricular function was changed in the later period of CKD patients, the change was significant in in the later period. The change of left ventricular configuration and function was closely associated with arterial stiffness. |
| Key words: Key words: Chronic kidney disease(CKD) Ultrasonic cardiogram Left ventriculus sinister Configuration Function Quantitative evaluation |
