Traditional nerve block technique is closely related to the clinical experience, with low success rate and relatively poor safety. In recent years, with the rapid development of ultrasound technology, ultrasound guided nerve block technology has been widely used and rapidly developped. The advent of ultrasound guided nerve block techniques has led to a fundamental change of nerve block in clinical application. The doctors could observe the peripheral nerve and its surrounding structure through ultrasound imaging, and perform the real time ultrasound imaging guided puncture to the target nerve to get an accurate nerve block without the injury to the surrounding tissue, thus the success rate of operation will be improved, the complications will be reduced, which greatly improves the efficiency of nerve block. In this paper, we will review the progress of clinical application of ultrasound guided nerve block.