| 摘要: |
| 目的: 探讨糖尿病患者血清基质金属蛋白酶-9(matrix metalopro-teinase-9,MMP-9) 与颈动脉弹性指标的相关性。方法: 选取糖尿病颈动脉内膜未见明显改变患者32例、内膜增厚及斑块形成患者45例及健康志愿者34例,酶联免疫吸附试验(ELISA)检测血清MMP-9 水平,同时应用血管回声跟踪技术(Echo-tracking, ET)检测颈动脉僵硬度(β)、压力应变弹性系数( Ep)、 顺应性(AC)、 增大指数(AI)及脉搏波传导速度( PWVβ) ,分析糖尿病患者血清MMP-9 与颈动脉弹性指标的相关性。结果: 与健康组比较, 糖尿病内膜正常组 Ep、 AI、 PWVβ 值增高、 MMP-9 水平增高, AC降低( P ＜0.05) ; 与糖尿病内膜正常组比较,内膜增生及斑块组β、Ep值、 PWVβ 值增高、MMP-9 水平增高, AC降低( P ＜0.05) 。糖尿病内膜正常患者血清MMP-9 水平与β、 AC、PWVβ 存在相关性( P ＜0.05),内膜增厚及斑块组血清MMP-9水平与Ep值、β、 AC存在相关性( P ＜0.05)。 结论: 糖尿病患者血清MMP-9 与颈动脉弹性功能存在相关性,可作为糖尿病患者早期发现动脉粥样硬化(AS)病变的敏感指标。 |
| 关键词: 糖尿病 动脉粥样硬化 基质金属蛋白酶-9 血管回升跟踪技术 颈动脉弹性 |
| DOI： |
| 投稿时间：2017-09-07修订日期：2018-04-15 |
| 基金项目:糖尿病超声影像的颈动脉壁弹性模型的应用研究 黑龙江省教育厅科学技术研究项目 |
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| Correlation of serum MMP-9 and carotid artery elasticity detected through vascular echo tracking technology in diabetic patients |
| ZHANG Yi-ran,SU Yan-xin |
| (Department of Ultrasound,the second Affiliated Hospital of Harbin Medical University) |
| Abstract: |
| Objective: To explore the relation of the level of serum matrix metalloproteinase-9( MMP-9), and artery elasticity function in diabetic patients. Methods: 34 healthy persons were enrolled in the control group, defined as the group A .77 diabetic patients were enrolled and divided into two groups: group B, 32 diabetic patients with normal thickness of carotid artery intima; group C, 45 diabetic patients with thickened carotid intima or atheromatousSplaque. The levels of MMP-9 were measured by means of (enzyme linked immunosorbent assay)ELISA. The blood vessel elastic modulus, including stiffness( β), pressure-strain elastic modulus ( Ep), arterial compliance( AC), increase index ( AI) , parameter ( PWVβ) were calculated by echo-tracking technique. Then the correlation between serum MMP-9 level and carotid artery elasticity index were analyzed. Results: The value of Ep, AI, PWVβ and the level of serum MMP-9 in group B were higher than those in healthy group,while the level of AC was lower than that in healthy group( P＜0.05). The value of β, Ep, PWVβ and the level of serum MMP-9 in group C were higher than those in group B; while the level of AC inwas lower than that in group B( P＜ 0.05) . The level of serum MMP-9 was related with β and PWVβ(P＜0.05) in group B, while these value were Ep, β, AI, PWVβ in group C. Conclusion: As it exist the correlation between artery elasticity function and serum MMP-9 level, the level of MMP-9 can be considered as a sensitive index to detect the atherosclerosis in early stage in diabetic patients. |
| Key words: Diabetes mellitus Atherosclerosis matrix metalloproteinase-9 Vascular echo tracking technology carotid artery elasticity |
