Objective: To investigate the correlation between the shear wave velocity of renal parenchyma and renal artery blood flow parameters in Diabetic nephropathy (DN).Materials and methods: We proactively measure multiparametric quantitative ultrasound markers with grayscale, spectral Doppler, and acoustic radiation force impulse imaging in 28 patients with DN and 28 healthy controls. Based on the urinary albumin and creatinine ratio (ACR),the patients with DN were divided into two groups: DN1 (ACR 30 mg/tendency or less) and DN2 (ACR > 30 mg/tendency). Multiparametric quantitative ultrasound parameters included kidney length, cortical thickness, parenchymal shear wave velocity, intrarenal artery peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index. We tested the difference in quantitative ultrasound parameters among DN1,DN2 and healthy controls using analysis of variance, analyzed correlations of renal artery blood flow parameters with SWV using Spearman correlation coefficients. Results: The resistance index (RI) at all levels of renal artery in DN patients were significantly higher than healthy controls, the PSV and EDV were significantly lower than healthy controls. Correlation analysis showed that the renal parenchyma SWV was negatively correlated with RI and positively correlated with PSV, PDV at all levels(p < 0.05) . There were significant difference in SWV between among the 3 groups (p < 0.05). Conclusions: Renal parenchyma SWV reduced with the aggravating of renal damage. There is a certain correlation between SWV of renal parenchyma and renal artery blood flow parameters. VTQ could help assess the degree of renal parenchyma damage in diabetic nephropathy .