| 摘要: |
| 目的：探讨糖尿病肾病(DN)中肾实质剪切波速度(SWV)与各级肾动脉血流参数的相关性。材料和方法：收集我院确诊为糖尿病肾病的病人28例,根据尿白蛋白与肌酐比值(ACR)将糖尿病肾病患者分为两组：DN1组(ACR≤30mg/mmol),DN2组(ACR＞30mg/mmol),另选择健康体检者28例作为对照组,依次进行频谱多普勒超声和声触诊组织定量技术(VTQ)检查,比较各组间肾实质SWV的变化,并分析肾实质SWV与各级肾动脉血流参数的相关性。结果：糖尿病肾病组各级肾动脉阻力指数(RI)均较对照组升高,收缩期最大峰值流速(PSV)与舒张期末血流速度(EDV)较对照组降低。相关性分析结果显示肾实质SWV与各级肾动脉RI呈负相关(p＜0.05),与各级肾动脉PSV、PDV呈正相关(p＜0.05)。糖尿病肾病患者肾皮质SWV均较对照组低,且均有统计学意义(p＜0.05)。结论：肾实质SWV随肾损害程度加重而减低,肾实质SWV与肾动脉血流参数存在一定相关性,VTQ有助于评估糖尿病肾病肾实质的损害程度。 |
| 关键词: 糖尿病肾病 剪切波速度 频谱多普勒超声 肾动脉 |
| DOI： |
| 投稿时间：2017-09-11修订日期：2017-09-14 |
| 基金项目: |
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| Correlation analysis between the shear wave velocity of renal parenchyma and renal artery blood flow parameters in Diabetic Nephropathy |
| yumengxia,Sun Hong-guang |
| (Department of Ultrasound, the Affiliated Hospital of Yangzhou University) |
| Abstract: |
| Objective: To investigate the correlation between the shear wave velocity of renal parenchyma and renal artery blood flow parameters in Diabetic nephropathy (DN).Materials and methods: We proactively measure multiparametric quantitative ultrasound markers with grayscale, spectral Doppler, and acoustic radiation force impulse imaging in 28 patients with DN and 28 healthy controls. Based on the urinary albumin and creatinine ratio (ACR),the patients with DN were divided into two groups: DN1 (ACR 30 mg/tendency or less) and DN2 (ACR > 30 mg/tendency). Multiparametric quantitative ultrasound parameters included kidney length, cortical thickness, parenchymal shear wave velocity, intrarenal artery peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index. We tested the difference in quantitative ultrasound parameters among DN1,DN2 and healthy controls using analysis of variance, analyzed correlations of renal artery blood flow parameters with SWV using Spearman correlation coefficients. Results: The resistance index (RI) at all levels of renal artery in DN patients were significantly higher than healthy controls, the PSV and EDV were significantly lower than healthy controls. Correlation analysis showed that the renal parenchyma SWV was negatively correlated with RI and positively correlated with PSV, PDV at all levels(p < 0.05) . There were significant difference in SWV between among the 3 groups (p < 0.05). Conclusions: Renal parenchyma SWV reduced with the aggravating of renal damage. There is a certain correlation between SWV of renal parenchyma and renal artery blood flow parameters. VTQ could help assess the degree of renal parenchyma damage in diabetic nephropathy . |
| Key words: Diabetic nephropathy Shear wave velocity Spectral Doppler ultrasound Renal artery. |
